Golub leukemia dataset analysis - Impact of Row Scaling

---

Whether to apply row-scaling on the matrix affects the clustering step in consensus partitioning, which might give different partition results on the samples. For the expression matrices, we recommend to scale rows because the more interesting thing is the subgrouping where genes show similar expression patterns in the sense of e.g. genes showing consistent up-regulation in the subgroups. If the rows are not scaled, the partitions are more generally affected by highly expressed genes.

In this analysis, we performed cola analysis on Golub Leukemia dataset by applying row-scaling on the matrix or not. The choice of row-scaling can be tuned by setting scale_rows to TRUE or FALSE in run_all_consensus_partition_methods() or consensus_partition() function.

For the partition methods hclust, kmeans, skmeans, pam and mclust, z-score scaling is applied as \((x-\mu)/\sigma\), and for NMF, the “min-max” scalling is applied as (x - min)/(max - min).

Consensus heatmaps for two subgroups

Figure 1A and 1B (switching the tabs in the following figure) illustrate consensus heatmaps for two-group classification with row-scaling or not. Table 1 lists the stability of consensus partition under different methods (measured by 1-PAC scores):

Table 1. 1-PAC scores of the consensus partitioning under each method. Partitions with 1-PAC > 0.9 are considered as stable partitions.

	Rows are scaled	Rows are unscaled
ATC:skmeans	1	0.67
ATC:kmeans	1	0.66
ATC:NMF	0.97	0.55
SD:skmeans	0.62	1
CV:skmeans	0.63	1
MAD:skmeans	0.64	1
SD:kmeans	0.66	1
CV:kmeans	0.65	1
MAD:kmeans	0.62	1
CV:mclust	0.49	0.98
MAD:mclust	0.82	0.96
SD:mclust	0.37	0.74
CV:NMF	0.63	0.68
MAD:NMF	0.68	0.65
SD:NMF	0.63	0.63
SD:pam	0.55	0.62
MAD:pam	0.65	0.58
CV:pam	0.55	0.55
MAD:hclust	0.23	0.53
ATC:pam	0.6	0.51
SD:hclust	0.24	0.44
ATC:hclust	0.57	0.4
CV:hclust	0.21	0.38
ATC:mclust	0.36	0.36

Rows are scaled

Figure 1A. Consensus heatmaps with two subgroups. Matrix rows are scaled.

Rows are unscaled

Figure 1B. Consensus heatmaps with two subgroups. Matrix rows are unscaled.

Classification from all methods

Figure 2 put classifications from all 24 methods as well as one clinical annotation. The annotation ALL.AML tells whether the patient (the sample) had ALL or AML. The lightness of the main heatmap corresponds to the silhouette scores for samples measured in each partition method. With lighter color, the less stable for the sample to stay in the same group.

When the matrix rows are scaled (top heatmap in Figure 2), there are two major sets of different classifications where methods integrated with mclust, kmeans, and NMF classify samples into two groups where one group mainly contains AML samples. Other methods integrated with ATC, skmeans and pam generate classifications where a subset of ALL samples move to the same group of AML samples. Although there are two different two-group classifications, the samples that have different classifications among methods generally have lower silhouette scores in the corresponding consensus partition runs ( i.e. the colors in the heatmap are lighter), which means, they are less confident samples for the classifications and different partition methods might classify them into different groups.

When the matrix are not scaled (bottom heatmap in Figure 2), the pattern is similar that there are also two sets of classifications. The difference to the top heatmap is now the partitions where features are selected based on row variance (SD/CV/MAD) are more stable in the consensus partitioning procedure while partitions with features selected by ATC are less stable.

Comparing classifications from row-scaling and non-row-scaling, the classifications are similar for both cases. Basically we can make the conclusion that, when rows are scaled, methods with ATC give more stable partitions and when rows are not scaled, methods with SD/CV/MAD give more stable partitions.

Figure 2. Classifications from all methods. Column order of the two heatmaps are the same.

To look closer on the different impact on consensus partitioning of applying row-scaling or not, We select the results by ATC:skmeans for the case when matrix rows are scaled and the results by MAD:kmeans for the case when matrix rows are not scaled. The partitionings are stable for the two methods in their settings. Figure 3 illustrates how the two classifications correspond.

Figure 3. Conseusus partitions from ATC:skmeans and MAD:kmeans methods.

We can confirm that MAD:kmeans, row unscaled classification fits very well to the AML/ALL classification, while a subset of ALL samples are classified as the same group as AML samples for the ATC:skmeans, row scaled classification.

To make it easier to describe, we term the classification from the scaled matrix as \(C_{s, 2}\) and the classification from the unscaled matrix as \(C_{u, 2}\).

We can confirm the separation of the two groups by PCA visualization. PCA is applied to the scaled matrix in Figure 4A and to the unscaled matrix in Figure 4B. The two plots shows the two classifications can both separate samples very well and seem very reasonable.

Figure 4. PCA plots for visualizing the two-group classification.

Signature genes

Since there are two different classifications, we can next look at the signature genes that are significantly differentially expressed in the two groups, i.e. to compare the signature genes that support the two different classifications.

In Figure 5A and 5B, the significant genes are simply selected by t-test. According to the heatmaps illustrated in Figure 5A and 5B, it seems the two different classification are all reasonable that there are many genes supporting them, although the number of significant genes in \(C_{s,2}\) are approximate 2 fold more than that in \(C_{u,2}\).

Rows are scaled

Figure 5A. Signature genes from C_{s,2}.

Rows are unscaled

Figure 5A. Signature genes from C_{u,2}.

The two sets of signature genes have quite large overlap, and they also have their own unique set of genes. \(C_{s,2}\) has 1106 (61%) specific genes and \(C_{u,2}\) has 353 (33%) specific genes (Figure 6).

Figure 6. Overlap of signature genes in C_{s,2} and C_{u,2}.

To see the difference of the three sets of signature genes in Figure 6, we make heatmaps for the signature genes specific in classification \(C_{s, 2}\), specific in \(C_{u, 2}\) and those common in the two classifications.

As illustrated in Figure 7A and 7C, the expression patterns for the signature genes specific in \(C_{s,2}\) or \(C_{u,2}\) are clean that the samples are not separable in the other classification, while in Figure 7B where the signature genes are shared by the two classifications, the signature genes show intermeidate expression patterns in the samples that disagree in the two classifcations, they can be classified to different groups by different methods.

Figure 7. Heatmaps of C_{s,2} specific signatures, C_{u,2} specific signatures and common signatures in the two classifcations.

We term the three categories of signature genes as group A/B/C and we apply Gene Ontology enrichment to the three set of genes by hypergenometric test (by the clusterProfiler package). We only use BP ontologies (Biological Process) and the significant GO terms are filtered by FDR < 0.01. The enriched GO terms are visualized as a heatmap in Figure 8 by their similarity to each other (by GOSemSim package). GO terms are split and categorized by their similarity clusters (see script here) with some of the terms highlighted as text.

Again, Figure 8 illustrates each set of genes have quite a lot enriched GO terms, which might imply both classification are biologically reasonable.

The complete list of the GO enrichment can be found at the end of this supplementary.

Figure 8. Gene ontology enrichment on the three sets of genes illustrated in Figure 7.

Conclusion

As a conclusion for the two-group classification analysis on Golub dataset, we can make following conclusions:

• partition methods that based on correlaions generate more stable partitions when rows are scaled.
• partition methods that based on row variance generate more stable partition when rows are not scaled.
• samples can both be separated by the two classifications, but from different aspect of views.
• both classifications have a amount of signature genes in common and different, and each set of genes have their own biological functions that are different from different set of genes.

Gene Ontology enrichment

A (649 terms)

ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	Count
GO:0009725	response to hormone	111/877	920/17913	0.0000	0.0000	111
GO:0051050	positive regulation of transport	111/877	942/17913	0.0000	0.0000	111
GO:0010243	response to organonitrogen compound	105/877	932/17913	0.0000	0.0000	105
GO:0071417	cellular response to organonitrogen compound	71/877	559/17913	0.0000	0.0000	71
GO:0033993	response to lipid	95/877	884/17913	0.0000	0.0000	95
GO:0007167	enzyme linked receptor protein signaling pathway	101/877	968/17913	0.0000	0.0000	101
GO:1901652	response to peptide	64/877	491/17913	0.0000	0.0000	64
GO:1901699	cellular response to nitrogen compound	74/877	620/17913	0.0000	0.0000	74
GO:0014070	response to organic cyclic compound	93/877	879/17913	0.0000	0.0000	93
GO:0023061	signal release	58/877	433/17913	0.0000	0.0000	58
GO:0070482	response to oxygen levels	54/877	389/17913	0.0000	0.0000	54
GO:0032870	cellular response to hormone stimulus	73/877	647/17913	0.0000	0.0000	73
GO:1903530	regulation of secretion by cell	77/877	703/17913	0.0000	0.0000	77
GO:0009611	response to wounding	74/877	665/17913	0.0000	0.0000	74
GO:0042493	response to drug	95/877	958/17913	0.0000	0.0000	95
GO:1901653	cellular response to peptide	50/877	364/17913	0.0000	0.0000	50
GO:0051046	regulation of secretion	80/877	757/17913	0.0000	0.0000	80
GO:0036293	response to decreased oxygen levels	49/877	365/17913	0.0000	0.0000	49
GO:0001666	response to hypoxia	48/877	354/17913	0.0000	0.0000	48
GO:0043434	response to peptide hormone	52/877	404/17913	0.0000	0.0000	52
GO:0046879	hormone secretion	43/877	301/17913	0.0000	0.0000	43
GO:0002790	peptide secretion	65/877	582/17913	0.0000	0.0000	65
GO:0090087	regulation of peptide transport	74/877	706/17913	0.0000	0.0000	74
GO:0051098	regulation of binding	48/877	368/17913	0.0000	0.0000	48
GO:0030072	peptide hormone secretion	37/877	241/17913	0.0000	0.0000	37
GO:0009914	hormone transport	43/877	311/17913	0.0000	0.0000	43
GO:0019725	cellular homeostasis	81/877	814/17913	0.0000	0.0000	81
GO:0042391	regulation of membrane potential	48/877	374/17913	0.0000	0.0000	48
GO:0043269	regulation of ion transport	68/877	639/17913	0.0000	0.0000	68
GO:0046883	regulation of hormone secretion	37/877	254/17913	0.0000	0.0000	37
GO:0043066	negative regulation of apoptotic process	85/877	894/17913	0.0000	0.0000	85
GO:0055082	cellular chemical homeostasis	69/877	666/17913	0.0000	0.0000	69
GO:0098657	import into cell	75/877	751/17913	0.0000	0.0000	75
GO:0061564	axon development	52/877	438/17913	0.0000	0.0000	52
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	69/877	669/17913	0.0000	0.0000	69
GO:0032880	regulation of protein localization	90/877	979/17913	0.0000	0.0000	90
GO:0007417	central nervous system development	87/877	935/17913	0.0000	0.0000	87
GO:0007409	axonogenesis	48/877	393/17913	0.0000	0.0000	48
GO:1903532	positive regulation of secretion by cell	47/877	381/17913	0.0000	0.0000	47
GO:0071375	cellular response to peptide hormone stimulus	40/877	297/17913	0.0000	0.0000	40
GO:0042327	positive regulation of phosphorylation	88/877	955/17913	0.0000	0.0000	88
GO:0048732	gland development	50/877	422/17913	0.0000	0.0000	50
GO:0060322	head development	73/877	738/17913	0.0000	0.0000	73
GO:0046887	positive regulation of hormone secretion	24/877	125/17913	0.0000	0.0000	24
GO:0043069	negative regulation of programmed cell death	85/877	916/17913	0.0000	0.0000	85
GO:0099536	synaptic signaling	63/877	601/17913	0.0000	0.0000	63
GO:0048534	hematopoietic or lymphoid organ development	83/877	890/17913	0.0000	0.0000	83
GO:0090276	regulation of peptide hormone secretion	31/877	199/17913	0.0000	0.0000	31
GO:0060341	regulation of cellular localization	81/877	863/17913	0.0000	0.0000	81
GO:0002520	immune system development	86/877	938/17913	0.0000	0.0000	86
GO:0007268	chemical synaptic transmission	62/877	591/17913	0.0000	0.0000	62
GO:0098916	anterograde trans-synaptic signaling	62/877	591/17913	0.0000	0.0000	62
GO:0048729	tissue morphogenesis	65/877	635/17913	0.0000	0.0000	65
GO:0050804	modulation of chemical synaptic transmission	47/877	393/17913	0.0000	0.0000	47
GO:0006936	muscle contraction	43/877	343/17913	0.0000	0.0000	43
GO:0009636	response to toxic substance	55/877	499/17913	0.0000	0.0000	55
GO:0099177	regulation of trans-synaptic signaling	47/877	394/17913	0.0000	0.0000	47
GO:0008285	negative regulation of cell proliferation	73/877	751/17913	0.0000	0.0000	73
GO:0070201	regulation of establishment of protein localization	71/877	723/17913	0.0000	0.0000	71
GO:0099537	trans-synaptic signaling	62/877	596/17913	0.0000	0.0000	62
GO:0048863	stem cell differentiation	34/877	237/17913	0.0000	0.0000	34
GO:0051047	positive regulation of secretion	48/877	409/17913	0.0000	0.0000	48
GO:0001505	regulation of neurotransmitter levels	41/877	321/17913	0.0000	0.0000	41
GO:0010817	regulation of hormone levels	55/877	503/17913	0.0000	0.0000	55
GO:0048511	rhythmic process	38/877	287/17913	0.0000	0.0000	38
GO:0030097	hemopoiesis	79/877	847/17913	0.0000	0.0000	79
GO:0032386	regulation of intracellular transport	47/877	400/17913	0.0000	0.0000	47
GO:0032868	response to insulin	35/877	252/17913	0.0000	0.0000	35
GO:0048545	response to steroid hormone	45/877	375/17913	0.0000	0.0000	45
GO:0099003	vesicle-mediated transport in synapse	28/877	174/17913	0.0000	0.0000	28
GO:0009306	protein secretion	58/877	549/17913	0.0000	0.0000	58
GO:0072358	cardiovascular system development	75/877	792/17913	0.0000	0.0000	75
GO:0044419	interspecies interaction between organisms	84/877	928/17913	0.0000	0.0000	84
GO:0006935	chemotaxis	58/877	551/17913	0.0000	0.0000	58
GO:0002791	regulation of peptide secretion	53/877	483/17913	0.0000	0.0000	53
GO:0034762	regulation of transmembrane transport	57/877	538/17913	0.0000	0.0000	57
GO:0042330	taxis	58/877	553/17913	0.0000	0.0000	58
GO:0001944	vasculature development	74/877	784/17913	0.0000	0.0000	74
GO:0035239	tube morphogenesis	82/877	905/17913	0.0000	0.0000	82
GO:0003012	muscle system process	50/877	448/17913	0.0000	0.0000	50
GO:0009743	response to carbohydrate	32/877	224/17913	0.0000	0.0000	32
GO:0072507	divalent inorganic cation homeostasis	47/877	412/17913	0.0000	0.0000	47
GO:0051223	regulation of protein transport	66/877	677/17913	0.0000	0.0000	66
GO:0008284	positive regulation of cell proliferation	83/877	931/17913	0.0000	0.0000	83
GO:0007420	brain development	67/877	694/17913	0.0000	0.0000	67
GO:0006836	neurotransmitter transport	33/877	241/17913	0.0000	0.0000	33
GO:0072503	cellular divalent inorganic cation homeostasis	45/877	392/17913	0.0000	0.0000	45
GO:0043270	positive regulation of ion transport	35/877	266/17913	0.0000	0.0000	35
GO:0009266	response to temperature stimulus	31/877	219/17913	0.0000	0.0000	31
GO:0001568	blood vessel development	70/877	751/17913	0.0000	0.0000	70
GO:0016579	protein deubiquitination	34/877	260/17913	0.0000	0.0000	34
GO:1904951	positive regulation of establishment of protein localization	48/877	440/17913	0.0000	0.0000	48
GO:0032101	regulation of response to external stimulus	78/877	873/17913	0.0000	0.0000	78
GO:0070646	protein modification by small protein removal	35/877	273/17913	0.0000	0.0000	35
GO:0030001	metal ion transport	73/877	800/17913	0.0000	0.0000	73
GO:0001934	positive regulation of protein phosphorylation	80/877	907/17913	0.0000	0.0000	80
GO:0045471	response to ethanol	22/877	127/17913	0.0000	0.0000	22
GO:0050878	regulation of body fluid levels	52/877	499/17913	0.0000	0.0000	52
GO:0048514	blood vessel morphogenesis	64/877	670/17913	0.0000	0.0000	64
GO:0033674	positive regulation of kinase activity	55/877	541/17913	0.0000	0.0000	55
GO:0010959	regulation of metal ion transport	42/877	365/17913	0.0000	0.0000	42
GO:0018209	peptidyl-serine modification	33/877	252/17913	0.0000	0.0000	33
GO:0046677	response to antibiotic	39/877	328/17913	0.0000	0.0000	39
GO:0044403	symbiont process	78/877	884/17913	0.0000	0.0000	78
GO:0050778	positive regulation of immune response	73/877	809/17913	0.0000	0.0000	73
GO:0009894	regulation of catabolic process	80/877	916/17913	0.0000	0.0000	80
GO:0003013	circulatory system process	54/877	532/17913	0.0000	0.0000	54
GO:0030003	cellular cation homeostasis	53/877	518/17913	0.0000	0.0000	53
GO:0071407	cellular response to organic cyclic compound	54/877	533/17913	0.0000	0.0000	54
GO:0001525	angiogenesis	57/877	576/17913	0.0000	0.0000	57
GO:0090277	positive regulation of peptide hormone secretion	18/877	91/17913	0.0000	0.0000	18
GO:2001233	regulation of apoptotic signaling pathway	44/877	397/17913	0.0000	0.0000	44
GO:0031329	regulation of cellular catabolic process	73/877	814/17913	0.0000	0.0000	73
GO:0097190	apoptotic signaling pathway	57/877	579/17913	0.0000	0.0000	57
GO:0006875	cellular metal ion homeostasis	49/877	467/17913	0.0000	0.0000	49
GO:0048608	reproductive structure development	46/877	426/17913	0.0000	0.0000	46
GO:0051347	positive regulation of transferase activity	59/877	609/17913	0.0000	0.0000	59
GO:0055074	calcium ion homeostasis	43/877	388/17913	0.0000	0.0000	43
GO:0061458	reproductive system development	46/877	429/17913	0.0000	0.0000	46
GO:0030073	insulin secretion	28/877	200/17913	0.0000	0.0000	28
GO:0034284	response to monosaccharide	28/877	200/17913	0.0000	0.0000	28
GO:0000165	MAPK cascade	77/877	882/17913	0.0000	0.0000	77
GO:0007507	heart development	55/877	556/17913	0.0000	0.0000	55
GO:0048667	cell morphogenesis involved in neuron differentiation	51/877	500/17913	0.0000	0.0000	51
GO:0071453	cellular response to oxygen levels	31/877	237/17913	0.0000	0.0000	31
GO:0031347	regulation of defense response	77/877	885/17913	0.0000	0.0000	77
GO:0071363	cellular response to growth factor stimulus	63/877	674/17913	0.0000	0.0000	63
GO:0009749	response to glucose	27/877	190/17913	0.0000	0.0000	27
GO:0023014	signal transduction by protein phosphorylation	77/877	886/17913	0.0000	0.0000	77
GO:1902803	regulation of synaptic vesicle transport	16/877	76/17913	0.0000	0.0000	16
GO:0002793	positive regulation of peptide secretion	34/877	275/17913	0.0000	0.0000	34
GO:0006873	cellular ion homeostasis	53/877	531/17913	0.0000	0.0000	53
GO:0000904	cell morphogenesis involved in differentiation	60/877	632/17913	0.0000	0.0000	60
GO:0002253	activation of immune response	61/877	647/17913	0.0000	0.0000	61
GO:0042593	glucose homeostasis	30/877	227/17913	0.0000	0.0000	30
GO:0071396	cellular response to lipid	56/877	576/17913	0.0000	0.0000	56
GO:0009755	hormone-mediated signaling pathway	29/877	216/17913	0.0000	0.0000	29
GO:0033500	carbohydrate homeostasis	30/877	228/17913	0.0000	0.0000	30
GO:0006942	regulation of striated muscle contraction	18/877	96/17913	0.0000	0.0000	18
GO:0043065	positive regulation of apoptotic process	61/877	652/17913	0.0000	0.0000	61
GO:0044057	regulation of system process	57/877	594/17913	0.0000	0.0000	57
GO:0031667	response to nutrient levels	48/877	466/17913	0.0000	0.0000	48
GO:1903522	regulation of blood circulation	35/877	292/17913	0.0000	0.0000	35
GO:0009887	animal organ morphogenesis	83/877	989/17913	0.0000	0.0000	83
GO:0008015	blood circulation	52/877	523/17913	0.0000	0.0000	52
GO:0009746	response to hexose	27/877	195/17913	0.0000	0.0000	27
GO:0018105	peptidyl-serine phosphorylation	30/877	231/17913	0.0000	0.0000	30
GO:0016032	viral process	72/877	822/17913	0.0000	0.0000	72
GO:0002009	morphogenesis of an epithelium	52/877	527/17913	0.0000	0.0000	52
GO:0032869	cellular response to insulin stimulus	27/877	197/17913	0.0000	0.0000	27
GO:0006874	cellular calcium ion homeostasis	41/877	375/17913	0.0000	0.0000	41
GO:0070848	response to growth factor	64/877	704/17913	0.0000	0.0000	64
GO:0001816	cytokine production	68/877	765/17913	0.0000	0.0001	68
GO:0043068	positive regulation of programmed cell death	61/877	660/17913	0.0000	0.0001	61
GO:0051222	positive regulation of protein transport	43/877	403/17913	0.0000	0.0001	43
GO:0071214	cellular response to abiotic stimulus	36/877	310/17913	0.0000	0.0001	36
GO:0104004	cellular response to environmental stimulus	36/877	310/17913	0.0000	0.0001	36
GO:0120039	plasma membrane bounded cell projection morphogenesis	55/877	573/17913	0.0000	0.0001	55
GO:0000902	cell morphogenesis	75/877	874/17913	0.0000	0.0001	75
GO:0055080	cation homeostasis	56/877	588/17913	0.0000	0.0001	56
GO:0048812	neuron projection morphogenesis	54/877	559/17913	0.0000	0.0001	54
GO:0006887	exocytosis	74/877	862/17913	0.0000	0.0001	74
GO:0048858	cell projection morphogenesis	55/877	577/17913	0.0000	0.0001	55
GO:0015672	monovalent inorganic cation transport	48/877	477/17913	0.0000	0.0001	48
GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	25/877	178/17913	0.0000	0.0001	25
GO:0042060	wound healing	53/877	550/17913	0.0000	0.0001	53
GO:0060627	regulation of vesicle-mediated transport	48/877	480/17913	0.0000	0.0001	48
GO:0040007	growth	79/877	948/17913	0.0000	0.0001	79
GO:0001101	response to acid chemical	37/877	330/17913	0.0000	0.0001	37
GO:0070838	divalent metal ion transport	46/877	454/17913	0.0000	0.0001	46
GO:0045786	negative regulation of cell cycle	57/877	613/17913	0.0000	0.0001	57
GO:0007568	aging	36/877	318/17913	0.0000	0.0001	36
GO:0009991	response to extracellular stimulus	49/877	498/17913	0.0000	0.0001	49
GO:0009408	response to heat	23/877	158/17913	0.0000	0.0001	23
GO:0043393	regulation of protein binding	28/877	217/17913	0.0000	0.0001	28
GO:0098771	inorganic ion homeostasis	56/877	600/17913	0.0000	0.0001	56
GO:0022898	regulation of transmembrane transporter activity	30/877	242/17913	0.0000	0.0001	30
GO:0006941	striated muscle contraction	24/877	170/17913	0.0000	0.0001	24
GO:0048771	tissue remodeling	24/877	170/17913	0.0000	0.0001	24
GO:0048489	synaptic vesicle transport	20/877	126/17913	0.0000	0.0001	20
GO:0097480	establishment of synaptic vesicle localization	20/877	126/17913	0.0000	0.0001	20
GO:0072511	divalent inorganic cation transport	46/877	458/17913	0.0000	0.0001	46
GO:0097479	synaptic vesicle localization	21/877	137/17913	0.0000	0.0001	21
GO:0045860	positive regulation of protein kinase activity	49/877	501/17913	0.0000	0.0001	49
GO:0000375	RNA splicing, via transesterification reactions	38/877	348/17913	0.0000	0.0001	38
GO:2000736	regulation of stem cell differentiation	19/877	116/17913	0.0000	0.0001	19
GO:0055065	metal ion homeostasis	51/877	531/17913	0.0000	0.0001	51
GO:0031175	neuron projection development	74/877	879/17913	0.0000	0.0001	74
GO:0010942	positive regulation of cell death	63/877	710/17913	0.0000	0.0001	63
GO:0036294	cellular response to decreased oxygen levels	28/877	220/17913	0.0000	0.0001	28
GO:0003015	heart process	33/877	284/17913	0.0000	0.0001	33
GO:0009308	amine metabolic process	20/877	128/17913	0.0000	0.0001	20
GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	23/877	162/17913	0.0000	0.0001	23
GO:0050801	ion homeostasis	60/877	669/17913	0.0000	0.0001	60
GO:1904062	regulation of cation transmembrane transport	35/877	312/17913	0.0000	0.0001	35
GO:0098655	cation transmembrane transport	64/877	730/17913	0.0000	0.0001	64
GO:0007411	axon guidance	27/877	210/17913	0.0000	0.0001	27
GO:0071456	cellular response to hypoxia	27/877	210/17913	0.0000	0.0001	27
GO:0032990	cell part morphogenesis	55/877	595/17913	0.0000	0.0001	55
GO:0030855	epithelial cell differentiation	65/877	746/17913	0.0000	0.0001	65
GO:0051588	regulation of neurotransmitter transport	20/877	129/17913	0.0000	0.0001	20
GO:0034764	positive regulation of transmembrane transport	26/877	199/17913	0.0000	0.0001	26
GO:0050670	regulation of lymphocyte proliferation	26/877	199/17913	0.0000	0.0001	26
GO:0008016	regulation of heart contraction	30/877	249/17913	0.0000	0.0001	30
GO:0019221	cytokine-mediated signaling pathway	66/877	764/17913	0.0000	0.0001	66
GO:0050851	antigen receptor-mediated signaling pathway	28/877	224/17913	0.0000	0.0001	28
GO:0006937	regulation of muscle contraction	23/877	164/17913	0.0000	0.0001	23
GO:0007159	leukocyte cell-cell adhesion	36/877	328/17913	0.0000	0.0001	36
GO:0097485	neuron projection guidance	27/877	212/17913	0.0000	0.0001	27
GO:0009612	response to mechanical stimulus	26/877	200/17913	0.0000	0.0001	26
GO:0032944	regulation of mononuclear cell proliferation	26/877	200/17913	0.0000	0.0001	26
GO:0034765	regulation of ion transmembrane transport	45/877	453/17913	0.0000	0.0001	45
GO:2000027	regulation of animal organ morphogenesis	30/877	250/17913	0.0000	0.0001	30
GO:0098810	neurotransmitter reuptake	8/877	22/17913	0.0000	0.0001	8
GO:0051101	regulation of DNA binding	19/877	120/17913	0.0000	0.0002	19
GO:0006897	endocytosis	60/877	675/17913	0.0000	0.0002	60
GO:2001020	regulation of response to DNA damage stimulus	26/877	201/17913	0.0000	0.0002	26
GO:0045087	innate immune response	74/877	893/17913	0.0000	0.0002	74
GO:0045055	regulated exocytosis	66/877	768/17913	0.0000	0.0002	66
GO:0098660	inorganic ion transmembrane transport	63/877	722/17913	0.0000	0.0002	63
GO:0006954	inflammatory response	67/877	784/17913	0.0000	0.0002	67
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	37/877	344/17913	0.0000	0.0002	37
GO:0000398	mRNA splicing, via spliceosome	37/877	344/17913	0.0000	0.0002	37
GO:0070663	regulation of leukocyte proliferation	27/877	214/17913	0.0000	0.0002	27
GO:0050708	regulation of protein secretion	45/877	456/17913	0.0000	0.0002	45
GO:0044106	cellular amine metabolic process	19/877	121/17913	0.0000	0.0002	19
GO:0060048	cardiac muscle contraction	20/877	132/17913	0.0000	0.0002	20
GO:0090066	regulation of anatomical structure size	44/877	442/17913	0.0000	0.0002	44
GO:0033238	regulation of cellular amine metabolic process	15/877	80/17913	0.0000	0.0002	15
GO:0051090	regulation of DNA-binding transcription factor activity	43/877	429/17913	0.0000	0.0002	43
GO:0003006	developmental process involved in reproduction	58/877	649/17913	0.0000	0.0002	58
GO:0006816	calcium ion transport	42/877	415/17913	0.0000	0.0002	42
GO:2000300	regulation of synaptic vesicle exocytosis	14/877	71/17913	0.0000	0.0002	14
GO:0045597	positive regulation of cell differentiation	78/877	962/17913	0.0000	0.0002	78
GO:0071496	cellular response to external stimulus	35/877	320/17913	0.0000	0.0002	35
GO:0055117	regulation of cardiac muscle contraction	15/877	81/17913	0.0000	0.0002	15
GO:0001656	metanephros development	16/877	91/17913	0.0000	0.0002	16
GO:0050806	positive regulation of synaptic transmission	21/877	145/17913	0.0000	0.0002	21
GO:0001817	regulation of cytokine production	61/877	698/17913	0.0000	0.0002	61
GO:0050796	regulation of insulin secretion	23/877	169/17913	0.0000	0.0002	23
GO:1905330	regulation of morphogenesis of an epithelium	24/877	181/17913	0.0000	0.0002	24
GO:0043549	regulation of kinase activity	68/877	808/17913	0.0000	0.0002	68
GO:0046651	lymphocyte proliferation	29/877	244/17913	0.0000	0.0002	29
GO:0051924	regulation of calcium ion transport	29/877	244/17913	0.0000	0.0002	29
GO:0070661	leukocyte proliferation	31/877	270/17913	0.0000	0.0002	31
GO:0032409	regulation of transporter activity	30/877	257/17913	0.0000	0.0002	30
GO:0031669	cellular response to nutrient levels	27/877	220/17913	0.0000	0.0002	27
GO:0032943	mononuclear cell proliferation	29/877	246/17913	0.0000	0.0003	29
GO:0016071	mRNA metabolic process	68/877	815/17913	0.0000	0.0003	68
GO:0043620	regulation of DNA-templated transcription in response to stress	18/877	115/17913	0.0000	0.0003	18
GO:0050900	leukocyte migration	45/877	467/17913	0.0000	0.0003	45
GO:0042129	regulation of T cell proliferation	21/877	149/17913	0.0000	0.0003	21
GO:1903706	regulation of hemopoiesis	45/877	468/17913	0.0000	0.0003	45
GO:0032989	cellular component morphogenesis	77/877	960/17913	0.0000	0.0003	77
GO:0006886	intracellular protein transport	69/877	833/17913	0.0000	0.0003	69
GO:0007221	positive regulation of transcription of Notch receptor target	7/877	18/17913	0.0000	0.0003	7
GO:2001234	negative regulation of apoptotic signaling pathway	27/877	223/17913	0.0000	0.0003	27
GO:0002764	immune response-regulating signaling pathway	54/877	603/17913	0.0000	0.0003	54
GO:0010469	regulation of signaling receptor activity	53/877	588/17913	0.0000	0.0003	53
GO:0060047	heart contraction	31/877	275/17913	0.0000	0.0003	31
GO:0051100	negative regulation of binding	22/877	162/17913	0.0000	0.0003	22
GO:0006913	nucleocytoplasmic transport	33/877	302/17913	0.0000	0.0003	33
GO:0071322	cellular response to carbohydrate stimulus	20/877	139/17913	0.0000	0.0003	20
GO:0098693	regulation of synaptic vesicle cycle	17/877	106/17913	0.0000	0.0003	17
GO:0090257	regulation of muscle system process	29/877	251/17913	0.0000	0.0003	29
GO:0017144	drug metabolic process	66/877	792/17913	0.0000	0.0003	66
GO:0048013	ephrin receptor signaling pathway	15/877	86/17913	0.0000	0.0004	15
GO:0051169	nuclear transport	33/877	305/17913	0.0000	0.0004	33
GO:0045785	positive regulation of cell adhesion	39/877	388/17913	0.0000	0.0004	39
GO:0048589	developmental growth	55/877	624/17913	0.0000	0.0004	55
GO:0042098	T cell proliferation	23/877	177/17913	0.0000	0.0004	23
GO:0046683	response to organophosphorus	19/877	130/17913	0.0000	0.0004	19
GO:0045859	regulation of protein kinase activity	62/877	733/17913	0.0000	0.0004	62
GO:0060284	regulation of cell development	72/877	893/17913	0.0000	0.0004	72
GO:0048872	homeostasis of number of cells	28/877	241/17913	0.0000	0.0004	28
GO:0002757	immune response-activating signal transduction	51/877	567/17913	0.0000	0.0004	51
GO:0098662	inorganic cation transmembrane transport	56/877	643/17913	0.0000	0.0004	56
GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress	17/877	109/17913	0.0000	0.0004	17
GO:0030163	protein catabolic process	66/877	799/17913	0.0000	0.0004	66
GO:0009314	response to radiation	42/877	435/17913	0.0000	0.0004	42
GO:0007548	sex differentiation	30/877	269/17913	0.0000	0.0005	30
GO:0030258	lipid modification	24/877	192/17913	0.0000	0.0005	24
GO:0040017	positive regulation of locomotion	51/877	570/17913	0.0000	0.0005	51
GO:1903169	regulation of calcium ion transmembrane transport	20/877	144/17913	0.0000	0.0005	20
GO:2000147	positive regulation of cell motility	49/877	540/17913	0.0000	0.0005	49
GO:0051272	positive regulation of cellular component movement	50/877	555/17913	0.0000	0.0005	50
GO:0050852	T cell receptor signaling pathway	23/877	180/17913	0.0000	0.0005	23
GO:0006352	DNA-templated transcription, initiation	27/877	231/17913	0.0000	0.0005	27
GO:0034612	response to tumor necrosis factor	31/877	284/17913	0.0000	0.0005	31
GO:0043401	steroid hormone mediated signaling pathway	23/877	181/17913	0.0000	0.0005	23
GO:0051099	positive regulation of binding	23/877	181/17913	0.0000	0.0005	23
GO:0046822	regulation of nucleocytoplasmic transport	16/877	100/17913	0.0000	0.0005	16
GO:0018149	peptide cross-linking	9/877	34/17913	0.0000	0.0005	9
GO:0030522	intracellular receptor signaling pathway	30/877	272/17913	0.0000	0.0006	30
GO:0008380	RNA splicing	42/877	440/17913	0.0000	0.0006	42
GO:0071560	cellular response to transforming growth factor beta stimulus	27/877	233/17913	0.0000	0.0006	27
GO:0002026	regulation of the force of heart contraction	8/877	27/17913	0.0000	0.0006	8
GO:0072207	metanephric epithelium development	8/877	27/17913	0.0000	0.0006	8
GO:0070555	response to interleukin-1	23/877	183/17913	0.0000	0.0006	23
GO:0043433	negative regulation of DNA-binding transcription factor activity	22/877	171/17913	0.0000	0.0006	22
GO:1903311	regulation of mRNA metabolic process	30/877	275/17913	0.0000	0.0007	30
GO:0033555	multicellular organismal response to stress	13/877	71/17913	0.0000	0.0007	13
GO:0051952	regulation of amine transport	13/877	71/17913	0.0000	0.0007	13
GO:0045664	regulation of neuron differentiation	53/877	609/17913	0.0000	0.0007	53
GO:0051480	regulation of cytosolic calcium ion concentration	31/877	289/17913	0.0000	0.0007	31
GO:0032526	response to retinoic acid	16/877	103/17913	0.0000	0.0007	16
GO:0048857	neural nucleus development	12/877	62/17913	0.0000	0.0007	12
GO:1905114	cell surface receptor signaling pathway involved in cell-cell signaling	52/877	596/17913	0.0000	0.0007	52
GO:0019932	second-messenger-mediated signaling	36/877	360/17913	0.0000	0.0007	36
GO:1902036	regulation of hematopoietic stem cell differentiation	13/877	72/17913	0.0000	0.0008	13
GO:0030155	regulation of cell adhesion	56/877	659/17913	0.0000	0.0008	56
GO:0002696	positive regulation of leukocyte activation	32/877	305/17913	0.0000	0.0008	32
GO:0022409	positive regulation of cell-cell adhesion	28/877	251/17913	0.0000	0.0008	28
GO:0031668	cellular response to extracellular stimulus	28/877	251/17913	0.0000	0.0008	28
GO:0051591	response to cAMP	15/877	93/17913	0.0000	0.0008	15
GO:0030879	mammary gland development	19/877	138/17913	0.0000	0.0008	19
GO:0070252	actin-mediated cell contraction	17/877	115/17913	0.0000	0.0008	17
GO:0044706	multi-multicellular organism process	26/877	225/17913	0.0000	0.0008	26
GO:0099504	synaptic vesicle cycle	21/877	162/17913	0.0000	0.0008	21
GO:0017157	regulation of exocytosis	23/877	187/17913	0.0000	0.0008	23
GO:0002768	immune response-regulating cell surface receptor signaling pathway	41/877	434/17913	0.0000	0.0008	41
GO:0046649	lymphocyte activation	54/877	630/17913	0.0000	0.0008	54
GO:0060218	hematopoietic stem cell differentiation	14/877	83/17913	0.0000	0.0008	14
GO:0060078	regulation of postsynaptic membrane potential	18/877	127/17913	0.0000	0.0008	18
GO:0071559	response to transforming growth factor beta	27/877	239/17913	0.0000	0.0008	27
GO:0050727	regulation of inflammatory response	44/877	479/17913	0.0000	0.0008	44
GO:0071356	cellular response to tumor necrosis factor	29/877	266/17913	0.0000	0.0008	29
GO:2001236	regulation of extrinsic apoptotic signaling pathway	20/877	151/17913	0.0000	0.0008	20
GO:1903039	positive regulation of leukocyte cell-cell adhesion	25/877	214/17913	0.0001	0.0009	25
GO:0051168	nuclear export	22/877	176/17913	0.0001	0.0009	22
GO:0007599	hemostasis	34/877	336/17913	0.0001	0.0009	34
GO:0051338	regulation of transferase activity	71/877	903/17913	0.0001	0.0009	71
GO:0051707	response to other organism	71/877	903/17913	0.0001	0.0009	71
GO:1901019	regulation of calcium ion transmembrane transporter activity	14/877	84/17913	0.0001	0.0009	14
GO:1903037	regulation of leukocyte cell-cell adhesion	31/877	295/17913	0.0001	0.0009	31
GO:0043207	response to external biotic stimulus	71/877	905/17913	0.0001	0.0009	71
GO:0051590	positive regulation of neurotransmitter transport	9/877	37/17913	0.0001	0.0009	9
GO:0080135	regulation of cellular response to stress	59/877	713/17913	0.0001	0.0009	59
GO:0010720	positive regulation of cell development	47/877	528/17913	0.0001	0.0010	47
GO:0072593	reactive oxygen species metabolic process	29/877	269/17913	0.0001	0.0010	29
GO:0032388	positive regulation of intracellular transport	24/877	203/17913	0.0001	0.0010	24
GO:0045766	positive regulation of angiogenesis	24/877	203/17913	0.0001	0.0010	24
GO:0006397	mRNA processing	45/877	499/17913	0.0001	0.0010	45
GO:0043410	positive regulation of MAPK cascade	45/877	499/17913	0.0001	0.0010	45
GO:0010332	response to gamma radiation	11/877	55/17913	0.0001	0.0010	11
GO:0006367	transcription initiation from RNA polymerase II promoter	22/877	178/17913	0.0001	0.0010	22
GO:0040008	regulation of growth	56/877	668/17913	0.0001	0.0010	56
GO:1901532	regulation of hematopoietic progenitor cell differentiation	14/877	85/17913	0.0001	0.0010	14
GO:0033002	muscle cell proliferation	27/877	243/17913	0.0001	0.0010	27
GO:0046928	regulation of neurotransmitter secretion	15/877	96/17913	0.0001	0.0010	15
GO:0008361	regulation of cell size	20/877	154/17913	0.0001	0.0010	20
GO:0071300	cellular response to retinoic acid	12/877	65/17913	0.0001	0.0010	12
GO:0001678	cellular glucose homeostasis	19/877	142/17913	0.0001	0.0010	19
GO:1901796	regulation of signal transduction by p53 class mediator	22/877	179/17913	0.0001	0.0011	22
GO:0045926	negative regulation of growth	27/877	244/17913	0.0001	0.0011	27
GO:0051051	negative regulation of transport	45/877	502/17913	0.0001	0.0011	45
GO:0051251	positive regulation of lymphocyte activation	28/877	258/17913	0.0001	0.0011	28
GO:0071326	cellular response to monosaccharide stimulus	18/877	131/17913	0.0001	0.0011	18
GO:0031960	response to corticosteroid	20/877	155/17913	0.0001	0.0011	20
GO:0002429	immune response-activating cell surface receptor signaling pathway	38/877	399/17913	0.0001	0.0011	38
GO:0097305	response to alcohol	26/877	232/17913	0.0001	0.0012	26
GO:0007565	female pregnancy	23/877	193/17913	0.0001	0.0012	23
GO:0015837	amine transport	13/877	76/17913	0.0001	0.0012	13
GO:0050767	regulation of neurogenesis	62/877	768/17913	0.0001	0.0012	62
GO:0051129	negative regulation of cellular component organization	56/877	673/17913	0.0001	0.0012	56
GO:0071347	cellular response to interleukin-1	20/877	156/17913	0.0001	0.0012	20
GO:0051249	regulation of lymphocyte activation	38/877	401/17913	0.0001	0.0012	38
GO:0072215	regulation of metanephros development	7/877	23/17913	0.0001	0.0013	7
GO:0072243	metanephric nephron epithelium development	7/877	23/17913	0.0001	0.0013	7
GO:0001819	positive regulation of cytokine production	41/877	446/17913	0.0001	0.0013	41
GO:0032412	regulation of ion transmembrane transporter activity	26/877	234/17913	0.0001	0.0013	26
GO:1902041	regulation of extrinsic apoptotic signaling pathway via death domain receptors	11/877	57/17913	0.0001	0.0013	11
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	13/877	77/17913	0.0001	0.0013	13
GO:0014074	response to purine-containing compound	19/877	145/17913	0.0001	0.0013	19
GO:0035567	non-canonical Wnt signaling pathway	19/877	145/17913	0.0001	0.0013	19
GO:0001503	ossification	37/877	388/17913	0.0001	0.0013	37
GO:0001504	neurotransmitter uptake	9/877	39/17913	0.0001	0.0013	9
GO:0007596	blood coagulation	33/877	331/17913	0.0001	0.0013	33
GO:0009790	embryo development	74/877	968/17913	0.0001	0.0013	74
GO:0031103	axon regeneration	10/877	48/17913	0.0001	0.0014	10
GO:0022407	regulation of cell-cell adhesion	37/877	389/17913	0.0001	0.0014	37
GO:0030100	regulation of endocytosis	28/877	262/17913	0.0001	0.0014	28
GO:0043488	regulation of mRNA stability	20/877	158/17913	0.0001	0.0014	20
GO:0050867	positive regulation of cell activation	32/877	319/17913	0.0001	0.0015	32
GO:0046007	negative regulation of activated T cell proliferation	5/877	11/17913	0.0001	0.0015	5
GO:0050805	negative regulation of synaptic transmission	12/877	68/17913	0.0001	0.0015	12
GO:0016079	synaptic vesicle exocytosis	15/877	100/17913	0.0001	0.0015	15
GO:0001508	action potential	17/877	123/17913	0.0001	0.0015	17
GO:0015980	energy derivation by oxidation of organic compounds	28/877	264/17913	0.0001	0.0015	28
GO:0048660	regulation of smooth muscle cell proliferation	21/877	172/17913	0.0001	0.0015	21
GO:0050870	positive regulation of T cell activation	23/877	198/17913	0.0001	0.0016	23
GO:1902600	proton transmembrane transport	19/877	148/17913	0.0001	0.0017	19
GO:1903305	regulation of regulated secretory pathway	18/877	136/17913	0.0001	0.0017	18
GO:0071295	cellular response to vitamin	8/877	32/17913	0.0001	0.0017	8
GO:0050817	coagulation	33/877	337/17913	0.0001	0.0018	33
GO:0007269	neurotransmitter secretion	19/877	149/17913	0.0001	0.0018	19
GO:0048659	smooth muscle cell proliferation	21/877	174/17913	0.0001	0.0018	21
GO:0050673	epithelial cell proliferation	39/877	425/17913	0.0001	0.0018	39
GO:1901342	regulation of vasculature development	39/877	425/17913	0.0001	0.0018	39
GO:0017158	regulation of calcium ion-dependent exocytosis	14/877	91/17913	0.0001	0.0019	14
GO:0030335	positive regulation of cell migration	45/877	516/17913	0.0001	0.0019	45
GO:0099643	signal release from synapse	19/877	150/17913	0.0001	0.0019	19
GO:0007623	circadian rhythm	23/877	201/17913	0.0001	0.0019	23
GO:0002260	lymphocyte homeostasis	11/877	60/17913	0.0001	0.0019	11
GO:0006091	generation of precursor metabolites and energy	44/877	502/17913	0.0001	0.0020	44
GO:0045765	regulation of angiogenesis	36/877	383/17913	0.0001	0.0020	36
GO:0006611	protein export from nucleus	20/877	163/17913	0.0001	0.0020	20
GO:0043487	regulation of RNA stability	20/877	163/17913	0.0001	0.0020	20
GO:0099565	chemical synaptic transmission, postsynaptic	15/877	103/17913	0.0001	0.0020	15
GO:0015696	ammonium transport	13/877	81/17913	0.0001	0.0020	13
GO:0007584	response to nutrient	24/877	215/17913	0.0001	0.0020	24
GO:0060249	anatomical structure homeostasis	38/877	413/17913	0.0001	0.0020	38
GO:0019884	antigen processing and presentation of exogenous antigen	21/877	176/17913	0.0001	0.0020	21
GO:0050678	regulation of epithelial cell proliferation	35/877	369/17913	0.0001	0.0020	35
GO:0042110	T cell activation	40/877	443/17913	0.0001	0.0020	40
GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	8/877	33/17913	0.0001	0.0020	8
GO:0051954	positive regulation of amine transport	8/877	33/17913	0.0001	0.0020	8
GO:0050714	positive regulation of protein secretion	27/877	256/17913	0.0002	0.0021	27
GO:0097094	craniofacial suture morphogenesis	6/877	18/17913	0.0002	0.0021	6
GO:0051384	response to glucocorticoid	18/877	139/17913	0.0002	0.0021	18
GO:0017156	calcium ion regulated exocytosis	17/877	127/17913	0.0002	0.0021	17
GO:0051960	regulation of nervous system development	67/877	870/17913	0.0002	0.0021	67
GO:0071383	cellular response to steroid hormone stimulus	26/877	243/17913	0.0002	0.0021	26
GO:0006521	regulation of cellular amino acid metabolic process	11/877	61/17913	0.0002	0.0022	11
GO:0019395	fatty acid oxidation	14/877	93/17913	0.0002	0.0022	14
GO:0009607	response to biotic stimulus	71/877	938/17913	0.0002	0.0022	71
GO:0032355	response to estradiol	17/877	128/17913	0.0002	0.0023	17
GO:0071333	cellular response to glucose stimulus	17/877	128/17913	0.0002	0.0023	17
GO:0060485	mesenchyme development	27/877	258/17913	0.0002	0.0023	27
GO:0044257	cellular protein catabolic process	53/877	648/17913	0.0002	0.0024	53
GO:0034605	cellular response to heat	16/877	117/17913	0.0002	0.0024	16
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	14/877	94/17913	0.0002	0.0024	14
GO:0035265	organ growth	21/877	179/17913	0.0002	0.0024	21
GO:1901385	regulation of voltage-gated calcium channel activity	8/877	34/17913	0.0002	0.0024	8
GO:1904018	positive regulation of vasculature development	25/877	232/17913	0.0002	0.0024	25
GO:1903827	regulation of cellular protein localization	44/877	509/17913	0.0002	0.0025	44
GO:0030162	regulation of proteolysis	60/877	762/17913	0.0002	0.0025	60
GO:0071377	cellular response to glucagon stimulus	7/877	26/17913	0.0002	0.0025	7
GO:0072202	cell differentiation involved in metanephros development	7/877	26/17913	0.0002	0.0025	7
GO:0033209	tumor necrosis factor-mediated signaling pathway	20/877	167/17913	0.0002	0.0026	20
GO:0071331	cellular response to hexose stimulus	17/877	130/17913	0.0002	0.0026	17
GO:0007589	body fluid secretion	14/877	95/17913	0.0002	0.0027	14
GO:0034440	lipid oxidation	14/877	95/17913	0.0002	0.0027	14
GO:0060079	excitatory postsynaptic potential	14/877	95/17913	0.0002	0.0027	14
GO:2000696	regulation of epithelial cell differentiation involved in kidney development	6/877	19/17913	0.0002	0.0027	6
GO:1903829	positive regulation of cellular protein localization	31/877	318/17913	0.0002	0.0027	31
GO:0070997	neuron death	33/877	347/17913	0.0002	0.0027	33
GO:0031099	regeneration	22/877	194/17913	0.0002	0.0028	22
GO:1905475	regulation of protein localization to membrane	21/877	181/17913	0.0002	0.0028	21
GO:0019933	cAMP-mediated signaling	18/877	143/17913	0.0002	0.0028	18
GO:0010035	response to inorganic substance	45/877	528/17913	0.0002	0.0028	45
GO:0048738	cardiac muscle tissue development	24/877	221/17913	0.0002	0.0028	24
GO:0001906	cell killing	19/877	156/17913	0.0002	0.0029	19
GO:0048167	regulation of synaptic plasticity	20/877	169/17913	0.0002	0.0029	20
GO:0035850	epithelial cell differentiation involved in kidney development	9/877	44/17913	0.0002	0.0029	9
GO:0030048	actin filament-based movement	17/877	132/17913	0.0002	0.0031	17
GO:0060401	cytosolic calcium ion transport	19/877	157/17913	0.0002	0.0031	19
GO:0062012	regulation of small molecule metabolic process	39/877	439/17913	0.0002	0.0031	39
GO:0043254	regulation of protein complex assembly	37/877	409/17913	0.0002	0.0031	37
GO:0043408	regulation of MAPK cascade	55/877	689/17913	0.0002	0.0031	55
GO:0007610	behavior	48/877	578/17913	0.0003	0.0031	48
GO:0097529	myeloid leukocyte migration	20/877	170/17913	0.0003	0.0031	20
GO:0061005	cell differentiation involved in kidney development	10/877	54/17913	0.0003	0.0031	10
GO:0050863	regulation of T cell activation	30/877	307/17913	0.0003	0.0031	30
GO:0060123	regulation of growth hormone secretion	5/877	13/17913	0.0003	0.0031	5
GO:0060452	positive regulation of cardiac muscle contraction	5/877	13/17913	0.0003	0.0031	5
GO:0072182	regulation of nephron tubule epithelial cell differentiation	5/877	13/17913	0.0003	0.0031	5
GO:1900272	negative regulation of long-term synaptic potentiation	5/877	13/17913	0.0003	0.0031	5
GO:0050769	positive regulation of neurogenesis	40/877	455/17913	0.0003	0.0031	40
GO:0031348	negative regulation of defense response	25/877	237/17913	0.0003	0.0032	25
GO:0060402	calcium ion transport into cytosol	18/877	145/17913	0.0003	0.0032	18
GO:0046777	protein autophosphorylation	23/877	210/17913	0.0003	0.0032	23
GO:0002444	myeloid leukocyte mediated immunity	46/877	549/17913	0.0003	0.0033	46
GO:0048598	embryonic morphogenesis	47/877	565/17913	0.0003	0.0034	47
GO:0033762	response to glucagon	8/877	36/17913	0.0003	0.0034	8
GO:0046825	regulation of protein export from nucleus	8/877	36/17913	0.0003	0.0034	8
GO:0014823	response to activity	11/877	65/17913	0.0003	0.0034	11
GO:0002027	regulation of heart rate	14/877	98/17913	0.0003	0.0035	14
GO:0050865	regulation of cell activation	45/877	535/17913	0.0003	0.0035	45
GO:0010975	regulation of neuron projection development	40/877	458/17913	0.0003	0.0035	40
GO:0031102	neuron projection regeneration	10/877	55/17913	0.0003	0.0035	10
GO:0032615	interleukin-12 production	10/877	55/17913	0.0003	0.0035	10
GO:0098586	cellular response to virus	10/877	55/17913	0.0003	0.0035	10
GO:0051650	establishment of vesicle localization	26/877	253/17913	0.0003	0.0035	26
GO:0035270	endocrine system development	16/877	122/17913	0.0003	0.0035	16
GO:0048638	regulation of developmental growth	31/877	325/17913	0.0003	0.0037	31
GO:0003180	aortic valve morphogenesis	7/877	28/17913	0.0003	0.0037	7
GO:0060292	long-term synaptic depression	7/877	28/17913	0.0003	0.0037	7
GO:0045666	positive regulation of neuron differentiation	33/877	355/17913	0.0003	0.0038	33
GO:0006635	fatty acid beta-oxidation	11/877	66/17913	0.0003	0.0038	11
GO:0015844	monoamine transport	11/877	66/17913	0.0003	0.0038	11
GO:0001736	establishment of planar polarity	16/877	123/17913	0.0003	0.0038	16
GO:0007164	establishment of tissue polarity	16/877	123/17913	0.0003	0.0038	16
GO:0002694	regulation of leukocyte activation	42/877	492/17913	0.0003	0.0039	42
GO:0003018	vascular process in circulatory system	19/877	161/17913	0.0003	0.0040	19
GO:0002478	antigen processing and presentation of exogenous peptide antigen	20/877	174/17913	0.0003	0.0040	20
GO:0001755	neural crest cell migration	8/877	37/17913	0.0003	0.0040	8
GO:0051648	vesicle localization	27/877	270/17913	0.0004	0.0041	27
GO:1901214	regulation of neuron death	30/877	313/17913	0.0004	0.0041	30
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	14/877	100/17913	0.0004	0.0041	14
GO:0043062	extracellular structure organization	35/877	387/17913	0.0004	0.0042	35
GO:0048002	antigen processing and presentation of peptide antigen	21/877	188/17913	0.0004	0.0042	21
GO:0070268	cornification	15/877	112/17913	0.0004	0.0042	15
GO:0010506	regulation of autophagy	30/877	314/17913	0.0004	0.0043	30
GO:0007517	muscle organ development	36/877	403/17913	0.0004	0.0043	36
GO:0016042	lipid catabolic process	29/877	300/17913	0.0004	0.0044	29
GO:0002275	myeloid cell activation involved in immune response	45/877	542/17913	0.0004	0.0044	45
GO:0048588	developmental cell growth	23/877	216/17913	0.0004	0.0044	23
GO:0050671	positive regulation of lymphocyte proliferation	16/877	125/17913	0.0004	0.0045	16
GO:0048675	axon extension	14/877	101/17913	0.0004	0.0045	14
GO:0032535	regulation of cellular component size	30/877	315/17913	0.0004	0.0045	30
GO:0045333	cellular respiration	20/877	176/17913	0.0004	0.0045	20
GO:0016572	histone phosphorylation	8/877	38/17913	0.0004	0.0047	8
GO:0030901	midbrain development	13/877	90/17913	0.0004	0.0047	13
GO:0002683	negative regulation of immune system process	39/877	451/17913	0.0004	0.0047	39
GO:0009161	ribonucleoside monophosphate metabolic process	31/877	331/17913	0.0004	0.0047	31
GO:0030856	regulation of epithelial cell differentiation	18/877	151/17913	0.0004	0.0048	18
GO:0032024	positive regulation of insulin secretion	11/877	68/17913	0.0004	0.0048	11
GO:1903524	positive regulation of blood circulation	11/877	68/17913	0.0004	0.0048	11
GO:0032946	positive regulation of mononuclear cell proliferation	16/877	126/17913	0.0004	0.0048	16
GO:0097006	regulation of plasma lipoprotein particle levels	14/877	102/17913	0.0004	0.0048	14
GO:0009167	purine ribonucleoside monophosphate metabolic process	30/877	317/17913	0.0004	0.0048	30
GO:0032147	activation of protein kinase activity	29/877	303/17913	0.0005	0.0050	29
GO:0007369	gastrulation	20/877	178/17913	0.0005	0.0050	20
GO:0061013	regulation of mRNA catabolic process	20/877	178/17913	0.0005	0.0050	20
GO:0061138	morphogenesis of a branching epithelium	20/877	178/17913	0.0005	0.0050	20
GO:0034767	positive regulation of ion transmembrane transport	18/877	152/17913	0.0005	0.0051	18
GO:0009126	purine nucleoside monophosphate metabolic process	30/877	318/17913	0.0005	0.0051	30
GO:0043299	leukocyte degranulation	44/877	532/17913	0.0005	0.0053	44
GO:2001023	regulation of response to drug	12/877	80/17913	0.0005	0.0053	12
GO:0072073	kidney epithelium development	17/877	140/17913	0.0005	0.0053	17
GO:1904064	positive regulation of cation transmembrane transport	17/877	140/17913	0.0005	0.0053	17
GO:1902991	regulation of amyloid precursor protein catabolic process	7/877	30/17913	0.0005	0.0053	7
GO:0006974	cellular response to DNA damage stimulus	60/877	791/17913	0.0005	0.0054	60
GO:0019935	cyclic-nucleotide-mediated signaling	19/877	166/17913	0.0005	0.0054	19
GO:0045823	positive regulation of heart contraction	8/877	39/17913	0.0005	0.0054	8
GO:0019882	antigen processing and presentation	23/877	220/17913	0.0005	0.0054	23
GO:0033157	regulation of intracellular protein transport	23/877	220/17913	0.0005	0.0054	23
GO:0035637	multicellular organismal signaling	21/877	193/17913	0.0005	0.0055	21
GO:0010038	response to metal ion	31/877	335/17913	0.0005	0.0056	31
GO:2001022	positive regulation of response to DNA damage stimulus	13/877	92/17913	0.0005	0.0056	13
GO:0031214	biomineral tissue development	18/877	154/17913	0.0005	0.0058	18
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	5/877	15/17913	0.0006	0.0058	5
GO:0072160	nephron tubule epithelial cell differentiation	5/877	15/17913	0.0006	0.0058	5
GO:0061061	muscle structure development	51/877	647/17913	0.0006	0.0058	51
GO:0009416	response to light stimulus	29/877	307/17913	0.0006	0.0059	29
GO:0030518	intracellular steroid hormone receptor signaling pathway	16/877	129/17913	0.0006	0.0059	16
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	30/877	323/17913	0.0006	0.0063	30
GO:0009615	response to virus	30/877	323/17913	0.0006	0.0063	30
GO:0042987	amyloid precursor protein catabolic process	8/877	40/17913	0.0006	0.0063	8
GO:0050832	defense response to fungus	8/877	40/17913	0.0006	0.0063	8
GO:0046824	positive regulation of nucleocytoplasmic transport	10/877	60/17913	0.0006	0.0063	10
GO:0002443	leukocyte mediated immunity	61/877	814/17913	0.0006	0.0063	61
GO:0099084	postsynaptic specialization organization	7/877	31/17913	0.0006	0.0063	7
GO:1903708	positive regulation of hemopoiesis	20/877	182/17913	0.0006	0.0063	20
GO:0031670	cellular response to nutrient	11/877	71/17913	0.0006	0.0065	11
GO:0050771	negative regulation of axonogenesis	9/877	50/17913	0.0006	0.0065	9
GO:0051966	regulation of synaptic transmission, glutamatergic	9/877	50/17913	0.0006	0.0065	9
GO:0048640	negative regulation of developmental growth	13/877	94/17913	0.0006	0.0066	13
GO:0043200	response to amino acid	14/877	106/17913	0.0007	0.0067	14
GO:0055017	cardiac muscle tissue growth	14/877	106/17913	0.0007	0.0067	14
GO:0045165	cell fate commitment	24/877	238/17913	0.0007	0.0067	24
GO:0072170	metanephric tubule development	6/877	23/17913	0.0007	0.0068	6
GO:2000637	positive regulation of gene silencing by miRNA	6/877	23/17913	0.0007	0.0068	6
GO:0006119	oxidative phosphorylation	16/877	131/17913	0.0007	0.0068	16
GO:0050728	negative regulation of inflammatory response	19/877	170/17913	0.0007	0.0068	19
GO:0010212	response to ionizing radiation	17/877	144/17913	0.0007	0.0069	17
GO:0034622	cellular protein-containing complex assembly	69/877	952/17913	0.0007	0.0069	69
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	12/877	83/17913	0.0007	0.0069	12
GO:0051928	positive regulation of calcium ion transport	15/877	119/17913	0.0007	0.0070	15
GO:0007179	transforming growth factor beta receptor signaling pathway	20/877	184/17913	0.0007	0.0071	20
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	14/877	107/17913	0.0007	0.0072	14
GO:0009620	response to fungus	9/877	51/17913	0.0007	0.0074	9
GO:2000677	regulation of transcription regulatory region DNA binding	9/877	51/17913	0.0007	0.0074	9
GO:0010001	glial cell differentiation	22/877	212/17913	0.0007	0.0074	22
GO:0002244	hematopoietic progenitor cell differentiation	18/877	158/17913	0.0007	0.0074	18
GO:0002262	myeloid cell homeostasis	17/877	145/17913	0.0007	0.0074	17
GO:0003176	aortic valve development	7/877	32/17913	0.0008	0.0074	7
GO:0007190	activation of adenylate cyclase activity	7/877	32/17913	0.0008	0.0074	7
GO:0033028	myeloid cell apoptotic process	7/877	32/17913	0.0008	0.0074	7
GO:0046688	response to copper ion	7/877	32/17913	0.0008	0.0074	7
GO:0060562	epithelial tube morphogenesis	29/877	313/17913	0.0008	0.0075	29
GO:0006163	purine nucleotide metabolic process	43/877	528/17913	0.0008	0.0075	43
GO:0001776	leukocyte homeostasis	12/877	84/17913	0.0008	0.0075	12
GO:0090559	regulation of membrane permeability	12/877	84/17913	0.0008	0.0075	12
GO:0030252	growth hormone secretion	5/877	16/17913	0.0008	0.0075	5
GO:0045989	positive regulation of striated muscle contraction	5/877	16/17913	0.0008	0.0075	5
GO:0071871	response to epinephrine	5/877	16/17913	0.0008	0.0075	5
GO:0007204	positive regulation of cytosolic calcium ion concentration	25/877	255/17913	0.0008	0.0075	25
GO:0072521	purine-containing compound metabolic process	45/877	560/17913	0.0008	0.0075	45
GO:0002064	epithelial cell development	21/877	199/17913	0.0008	0.0075	21
GO:0048762	mesenchymal cell differentiation	21/877	199/17913	0.0008	0.0075	21
GO:0032102	negative regulation of response to external stimulus	31/877	343/17913	0.0008	0.0075	31
GO:0038093	Fc receptor signaling pathway	24/877	241/17913	0.0008	0.0076	24
GO:0097191	extrinsic apoptotic signaling pathway	22/877	213/17913	0.0008	0.0076	22
GO:0050880	regulation of blood vessel size	16/877	133/17913	0.0008	0.0076	16
GO:0016049	cell growth	39/877	466/17913	0.0008	0.0077	39
GO:0003208	cardiac ventricle morphogenesis	11/877	73/17913	0.0008	0.0077	11
GO:0002685	regulation of leukocyte migration	20/877	186/17913	0.0008	0.0077	20
GO:0010948	negative regulation of cell cycle process	31/877	344/17913	0.0008	0.0078	31
GO:0002687	positive regulation of leukocyte migration	15/877	121/17913	0.0008	0.0080	15
GO:0045596	negative regulation of cell differentiation	55/877	725/17913	0.0008	0.0081	55
GO:0060148	positive regulation of posttranscriptional gene silencing	6/877	24/17913	0.0009	0.0081	6
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	12/877	85/17913	0.0009	0.0081	12
GO:0035150	regulation of tube size	16/877	134/17913	0.0009	0.0081	16
GO:0070665	positive regulation of leukocyte proliferation	16/877	134/17913	0.0009	0.0081	16
GO:0019693	ribose phosphate metabolic process	43/877	531/17913	0.0009	0.0081	43
GO:0090175	regulation of establishment of planar polarity	14/877	109/17913	0.0009	0.0081	14
GO:0001909	leukocyte mediated cytotoxicity	13/877	97/17913	0.0009	0.0082	13
GO:1902750	negative regulation of cell cycle G2/M phase transition	13/877	97/17913	0.0009	0.0082	13
GO:0009150	purine ribonucleotide metabolic process	41/877	500/17913	0.0009	0.0083	41
GO:0042594	response to starvation	19/877	174/17913	0.0009	0.0084	19
GO:0007006	mitochondrial membrane organization	15/877	122/17913	0.0009	0.0085	15
GO:0060537	muscle tissue development	34/877	392/17913	0.0009	0.0086	34
GO:0050770	regulation of axonogenesis	17/877	148/17913	0.0009	0.0087	17
GO:0035690	cellular response to drug	32/877	362/17913	0.0009	0.0087	32
GO:0030432	peristalsis	4/877	10/17913	0.0009	0.0087	4
GO:0071639	positive regulation of monocyte chemotactic protein-1 production	4/877	10/17913	0.0009	0.0087	4
GO:0032602	chemokine production	12/877	86/17913	0.0010	0.0088	12
GO:0009895	negative regulation of catabolic process	27/877	288/17913	0.0010	0.0089	27
GO:0010522	regulation of calcium ion transport into cytosol	13/877	98/17913	0.0010	0.0089	13
GO:0006914	autophagy	39/877	471/17913	0.0010	0.0090	39
GO:0061919	process utilizing autophagic mechanism	39/877	471/17913	0.0010	0.0090	39
GO:0032655	regulation of interleukin-12 production	9/877	53/17913	0.0010	0.0090	9
GO:0042130	negative regulation of T cell proliferation	9/877	53/17913	0.0010	0.0090	9
GO:0044242	cellular lipid catabolic process	20/877	189/17913	0.0010	0.0091	20
GO:0032479	regulation of type I interferon production	15/877	123/17913	0.0010	0.0091	15
GO:0021762	substantia nigra development	8/877	43/17913	0.0010	0.0091	8
GO:1901028	regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	8/877	43/17913	0.0010	0.0091	8
GO:1904646	cellular response to amyloid-beta	8/877	43/17913	0.0010	0.0091	8
GO:0035264	multicellular organism growth	17/877	149/17913	0.0010	0.0092	17
GO:0010769	regulation of cell morphogenesis involved in differentiation	25/877	260/17913	0.0010	0.0093	25
GO:0002283	neutrophil activation involved in immune response	40/877	488/17913	0.0010	0.0093	40
GO:1905710	positive regulation of membrane permeability	10/877	64/17913	0.0010	0.0093	10
GO:0009123	nucleoside monophosphate metabolic process	31/877	349/17913	0.0010	0.0093	31
GO:0090185	negative regulation of kidney development	5/877	17/17913	0.0011	0.0094	5
GO:0030099	myeloid cell differentiation	35/877	411/17913	0.0011	0.0096	35
GO:0001963	synaptic transmission, dopaminergic	6/877	25/17913	0.0011	0.0096	6
GO:0097435	supramolecular fiber organization	44/877	553/17913	0.0011	0.0096	44
GO:0090316	positive regulation of intracellular protein transport	17/877	150/17913	0.0011	0.0097	17
GO:0032735	positive regulation of interleukin-12 production	7/877	34/17913	0.0011	0.0099	7
GO:0060428	lung epithelium development	7/877	34/17913	0.0011	0.0099	7
GO:0002366	leukocyte activation involved in immune response	52/877	684/17913	0.0011	0.0099	52
GO:0051937	catecholamine transport	9/877	54/17913	0.0011	0.0100	9
GO:0070206	protein trimerization	9/877	54/17913	0.0011	0.0100	9
GO:0099132	ATP hydrolysis coupled cation transmembrane transport	9/877	54/17913	0.0011	0.0100	9
GO:1904645	response to amyloid-beta	9/877	54/17913	0.0011	0.0100	9
GO:0030218	erythrocyte differentiation	14/877	112/17913	0.0011	0.0100	14
GO:0060419	heart growth	14/877	112/17913	0.0011	0.0100	14

B (565 terms)

ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	Count
GO:0006259	DNA metabolic process	90/588	964/17913	0.0000	0.0000	90
GO:0002366	leukocyte activation involved in immune response	73/588	684/17913	0.0000	0.0000	73
GO:0002263	cell activation involved in immune response	73/588	688/17913	0.0000	0.0000	73
GO:0000278	mitotic cell cycle	86/588	934/17913	0.0000	0.0000	86
GO:0010948	negative regulation of cell cycle process	49/588	344/17913	0.0000	0.0000	49
GO:1903047	mitotic cell cycle process	78/588	816/17913	0.0000	0.0000	78
GO:0044419	interspecies interaction between organisms	84/588	928/17913	0.0000	0.0000	84
GO:0044403	symbiont process	81/588	884/17913	0.0000	0.0000	81
GO:0002443	leukocyte mediated immunity	77/588	814/17913	0.0000	0.0000	77
GO:0016032	viral process	77/588	822/17913	0.0000	0.0000	77
GO:0002274	myeloid leukocyte activation	67/588	652/17913	0.0000	0.0000	67
GO:0036230	granulocyte activation	57/588	506/17913	0.0000	0.0000	57
GO:0002275	myeloid cell activation involved in immune response	59/588	542/17913	0.0000	0.0000	59
GO:0045055	regulated exocytosis	72/588	768/17913	0.0000	0.0000	72
GO:0042119	neutrophil activation	56/588	499/17913	0.0000	0.0000	56
GO:0043299	leukocyte degranulation	58/588	532/17913	0.0000	0.0000	58
GO:0044772	mitotic cell cycle phase transition	60/588	565/17913	0.0000	0.0000	60
GO:0002444	myeloid leukocyte mediated immunity	59/588	549/17913	0.0000	0.0000	59
GO:0044770	cell cycle phase transition	62/588	609/17913	0.0000	0.0000	62
GO:0002283	neutrophil activation involved in immune response	54/588	488/17913	0.0000	0.0000	54
GO:0006887	exocytosis	75/588	862/17913	0.0000	0.0000	75
GO:0043312	neutrophil degranulation	53/588	485/17913	0.0000	0.0000	53
GO:0002446	neutrophil mediated immunity	53/588	499/17913	0.0000	0.0000	53
GO:0010564	regulation of cell cycle process	68/588	764/17913	0.0000	0.0000	68
GO:1903311	regulation of mRNA metabolic process	37/588	275/17913	0.0000	0.0000	37
GO:1901991	negative regulation of mitotic cell cycle phase transition	34/588	235/17913	0.0000	0.0000	34
GO:0045786	negative regulation of cell cycle	58/588	613/17913	0.0000	0.0000	58
GO:0007346	regulation of mitotic cell cycle	58/588	622/17913	0.0000	0.0000	58
GO:0002244	hematopoietic progenitor cell differentiation	27/588	158/17913	0.0000	0.0000	27
GO:1901988	negative regulation of cell cycle phase transition	34/588	254/17913	0.0000	0.0000	34
GO:1901990	regulation of mitotic cell cycle phase transition	45/588	428/17913	0.0000	0.0000	45
GO:0030097	hemopoiesis	68/588	847/17913	0.0000	0.0000	68
GO:0045930	negative regulation of mitotic cell cycle	37/588	308/17913	0.0000	0.0000	37
GO:0016071	mRNA metabolic process	66/588	815/17913	0.0000	0.0000	66
GO:0045087	innate immune response	70/588	893/17913	0.0000	0.0000	70
GO:0033044	regulation of chromosome organization	37/588	311/17913	0.0000	0.0000	37
GO:0002520	immune system development	72/588	938/17913	0.0000	0.0000	72
GO:0060218	hematopoietic stem cell differentiation	19/588	83/17913	0.0000	0.0000	19
GO:1901987	regulation of cell cycle phase transition	46/588	464/17913	0.0000	0.0000	46
GO:0048534	hematopoietic or lymphoid organ development	69/588	890/17913	0.0000	0.0000	69
GO:0006260	DNA replication	33/588	260/17913	0.0000	0.0000	33
GO:1902036	regulation of hematopoietic stem cell differentiation	17/588	72/17913	0.0000	0.0000	17
GO:0019221	cytokine-mediated signaling pathway	61/588	764/17913	0.0000	0.0000	61
GO:0033993	response to lipid	67/588	884/17913	0.0000	0.0000	67
GO:0000122	negative regulation of transcription by RNA polymerase II	59/588	735/17913	0.0000	0.0000	59
GO:0009607	response to biotic stimulus	69/588	938/17913	0.0000	0.0000	69
GO:2001252	positive regulation of chromosome organization	25/588	169/17913	0.0000	0.0000	25
GO:0070198	protein localization to chromosome, telomeric region	11/588	28/17913	0.0000	0.0000	11
GO:1902749	regulation of cell cycle G2/M phase transition	27/588	202/17913	0.0000	0.0000	27
GO:0070482	response to oxygen levels	39/588	389/17913	0.0000	0.0000	39
GO:0000165	MAPK cascade	65/588	882/17913	0.0000	0.0000	65
GO:0023014	signal transduction by protein phosphorylation	65/588	886/17913	0.0000	0.0000	65
GO:2000736	regulation of stem cell differentiation	20/588	116/17913	0.0000	0.0000	20
GO:0002521	leukocyte differentiation	44/588	485/17913	0.0000	0.0000	44
GO:0006974	cellular response to DNA damage stimulus	60/588	791/17913	0.0000	0.0000	60
GO:0000082	G1/S transition of mitotic cell cycle	31/588	269/17913	0.0000	0.0000	31
GO:0042493	response to drug	68/588	958/17913	0.0000	0.0000	68
GO:0051052	regulation of DNA metabolic process	39/588	403/17913	0.0000	0.0000	39
GO:0044839	cell cycle G2/M phase transition	30/588	257/17913	0.0000	0.0000	30
GO:1901532	regulation of hematopoietic progenitor cell differentiation	17/588	85/17913	0.0000	0.0000	17
GO:0001666	response to hypoxia	36/588	354/17913	0.0000	0.0000	36
GO:0010389	regulation of G2/M transition of mitotic cell cycle	25/588	185/17913	0.0000	0.0000	25
GO:0030162	regulation of proteolysis	58/588	762/17913	0.0000	0.0000	58
GO:0044106	cellular amine metabolic process	20/588	121/17913	0.0000	0.0000	20
GO:0019439	aromatic compound catabolic process	52/588	655/17913	0.0000	0.0000	52
GO:0031329	regulation of cellular catabolic process	60/588	814/17913	0.0000	0.0000	60
GO:0043487	regulation of RNA stability	23/588	163/17913	0.0000	0.0000	23
GO:1903405	protein localization to nuclear body	7/588	10/17913	0.0000	0.0000	7
GO:1904851	positive regulation of establishment of protein localization to telomere	7/588	10/17913	0.0000	0.0000	7
GO:1904867	protein localization to Cajal body	7/588	10/17913	0.0000	0.0000	7
GO:0036293	response to decreased oxygen levels	36/588	365/17913	0.0000	0.0000	36
GO:0051054	positive regulation of DNA metabolic process	27/588	222/17913	0.0000	0.0000	27
GO:0051707	response to other organism	64/588	903/17913	0.0000	0.0000	64
GO:0006403	RNA localization	26/588	208/17913	0.0000	0.0000	26
GO:0000086	G2/M transition of mitotic cell cycle	28/588	238/17913	0.0000	0.0000	28
GO:0043207	response to external biotic stimulus	64/588	905/17913	0.0000	0.0000	64
GO:0033238	regulation of cellular amine metabolic process	16/588	80/17913	0.0000	0.0000	16
GO:0000723	telomere maintenance	22/588	154/17913	0.0000	0.0000	22
GO:0009308	amine metabolic process	20/588	128/17913	0.0000	0.0000	20
GO:0044843	cell cycle G1/S phase transition	31/588	288/17913	0.0000	0.0000	31
GO:0034502	protein localization to chromosome	16/588	82/17913	0.0000	0.0000	16
GO:0043488	regulation of mRNA stability	22/588	158/17913	0.0000	0.0000	22
GO:0060249	anatomical structure homeostasis	38/588	413/17913	0.0000	0.0000	38
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	34/588	344/17913	0.0000	0.0000	34
GO:0000398	mRNA splicing, via spliceosome	34/588	344/17913	0.0000	0.0000	34
GO:0070203	regulation of establishment of protein localization to telomere	7/588	11/17913	0.0000	0.0000	7
GO:0071103	DNA conformation change	30/588	279/17913	0.0000	0.0000	30
GO:0050684	regulation of mRNA processing	18/588	108/17913	0.0000	0.0000	18
GO:0046700	heterocycle catabolic process	50/588	641/17913	0.0000	0.0000	50
GO:0044270	cellular nitrogen compound catabolic process	50/588	642/17913	0.0000	0.0000	50
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	16/588	85/17913	0.0000	0.0000	16
GO:0000375	RNA splicing, via transesterification reactions	34/588	348/17913	0.0000	0.0000	34
GO:0019882	antigen processing and presentation	26/588	220/17913	0.0000	0.0000	26
GO:1901361	organic cyclic compound catabolic process	52/588	685/17913	0.0000	0.0000	52
GO:0032392	DNA geometric change	16/588	86/17913	0.0000	0.0000	16
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	15/588	75/17913	0.0000	0.0000	15
GO:0071897	DNA biosynthetic process	24/588	192/17913	0.0000	0.0000	24
GO:0010638	positive regulation of organelle organization	47/588	591/17913	0.0000	0.0000	47
GO:0046649	lymphocyte activation	49/588	630/17913	0.0000	0.0000	49
GO:0017144	drug metabolic process	57/588	792/17913	0.0000	0.0000	57
GO:2000573	positive regulation of DNA biosynthetic process	14/588	66/17913	0.0000	0.0000	14
GO:0042110	T cell activation	39/588	443/17913	0.0000	0.0000	39
GO:0006397	mRNA processing	42/588	499/17913	0.0000	0.0000	42
GO:0051169	nuclear transport	31/588	305/17913	0.0000	0.0000	31
GO:0070202	regulation of establishment of protein localization to chromosome	7/588	12/17913	0.0000	0.0000	7
GO:1904816	positive regulation of protein localization to chromosome, telomeric region	7/588	12/17913	0.0000	0.0000	7
GO:1990173	protein localization to nucleoplasm	7/588	12/17913	0.0000	0.0000	7
GO:0034655	nucleobase-containing compound catabolic process	47/588	598/17913	0.0000	0.0000	47
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	15/588	78/17913	0.0000	0.0000	15
GO:0032200	telomere organization	22/588	167/17913	0.0000	0.0000	22
GO:0070555	response to interleukin-1	23/588	183/17913	0.0000	0.0000	23
GO:0032204	regulation of telomere maintenance	15/588	79/17913	0.0000	0.0000	15
GO:0031145	anaphase-promoting complex-dependent catabolic process	15/588	81/17913	0.0000	0.0000	15
GO:0008380	RNA splicing	38/588	440/17913	0.0000	0.0000	38
GO:0045088	regulation of innate immune response	38/588	440/17913	0.0000	0.0000	38
GO:2000278	regulation of DNA biosynthetic process	17/588	106/17913	0.0000	0.0000	17
GO:0014070	response to organic cyclic compound	60/588	879/17913	0.0000	0.0000	60
GO:0006521	regulation of cellular amino acid metabolic process	13/588	61/17913	0.0000	0.0000	13
GO:1904356	regulation of telomere maintenance via telomere lengthening	13/588	61/17913	0.0000	0.0000	13
GO:0033365	protein localization to organelle	56/588	798/17913	0.0000	0.0000	56
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	16/588	95/17913	0.0000	0.0000	16
GO:0006913	nucleocytoplasmic transport	30/588	302/17913	0.0000	0.0000	30
GO:0048863	stem cell differentiation	26/588	237/17913	0.0000	0.0000	26
GO:0006457	protein folding	22/588	176/17913	0.0000	0.0000	22
GO:0006281	DNA repair	41/588	502/17913	0.0000	0.0000	41
GO:0006325	chromatin organization	52/588	722/17913	0.0000	0.0000	52
GO:0061013	regulation of mRNA catabolic process	22/588	178/17913	0.0000	0.0000	22
GO:0070201	regulation of establishment of protein localization	52/588	723/17913	0.0000	0.0000	52
GO:1902750	negative regulation of cell cycle G2/M phase transition	16/588	97/17913	0.0000	0.0000	16
GO:0050778	positive regulation of immune response	56/588	809/17913	0.0000	0.0000	56
GO:1904814	regulation of protein localization to chromosome, telomeric region	7/588	14/17913	0.0000	0.0000	7
GO:0009894	regulation of catabolic process	61/588	916/17913	0.0000	0.0000	61
GO:0010035	response to inorganic substance	42/588	528/17913	0.0000	0.0000	42
GO:0009314	response to radiation	37/588	435/17913	0.0000	0.0000	37
GO:0062012	regulation of small molecule metabolic process	37/588	439/17913	0.0000	0.0000	37
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	14/588	77/17913	0.0000	0.0000	14
GO:0071347	cellular response to interleukin-1	20/588	156/17913	0.0000	0.0000	20
GO:1904874	positive regulation of telomerase RNA localization to Cajal body	7/588	15/17913	0.0000	0.0000	7
GO:0050821	protein stabilization	21/588	171/17913	0.0000	0.0000	21
GO:1904358	positive regulation of telomere maintenance via telomere lengthening	10/588	37/17913	0.0000	0.0000	10
GO:0007417	central nervous system development	61/588	935/17913	0.0000	0.0000	61
GO:0002220	innate immune response activating cell surface receptor signaling pathway	17/588	116/17913	0.0000	0.0000	17
GO:0010833	telomere maintenance via telomere lengthening	14/588	79/17913	0.0000	0.0000	14
GO:0043069	negative regulation of programmed cell death	60/588	916/17913	0.0000	0.0000	60
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	13/588	69/17913	0.0000	0.0000	13
GO:0031647	regulation of protein stability	27/588	272/17913	0.0000	0.0000	27
GO:0070200	establishment of protein localization to telomere	7/588	16/17913	0.0000	0.0000	7
GO:0002237	response to molecule of bacterial origin	29/588	309/17913	0.0000	0.0000	29
GO:0034622	cellular protein-containing complex assembly	61/588	952/17913	0.0000	0.0000	61
GO:0010243	response to organonitrogen compound	60/588	932/17913	0.0000	0.0000	60
GO:0032880	regulation of protein localization	62/588	979/17913	0.0000	0.0000	62
GO:0030155	regulation of cell adhesion	47/588	659/17913	0.0000	0.0000	47
GO:0090407	organophosphate biosynthetic process	46/588	640/17913	0.0000	0.0000	46
GO:0045597	positive regulation of cell differentiation	61/588	962/17913	0.0000	0.0000	61
GO:0045862	positive regulation of proteolysis	30/588	333/17913	0.0000	0.0000	30
GO:0032206	positive regulation of telomere maintenance	11/588	51/17913	0.0000	0.0000	11
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	17/588	124/17913	0.0000	0.0000	17
GO:0009725	response to hormone	59/588	920/17913	0.0000	0.0000	59
GO:0002764	immune response-regulating signaling pathway	44/588	603/17913	0.0000	0.0000	44
GO:0006352	DNA-templated transcription, initiation	24/588	231/17913	0.0000	0.0000	24
GO:0043903	regulation of symbiosis, encompassing mutualism through parasitism	24/588	232/17913	0.0000	0.0000	24
GO:0007568	aging	29/588	318/17913	0.0000	0.0000	29
GO:0006278	RNA-dependent DNA biosynthetic process	13/588	74/17913	0.0000	0.0000	13
GO:0002253	activation of immune response	46/588	647/17913	0.0000	0.0000	46
GO:0002218	activation of innate immune response	29/588	319/17913	0.0000	0.0000	29
GO:1903706	regulation of hemopoiesis	37/588	468/17913	0.0000	0.0000	37
GO:0002223	stimulatory C-type lectin receptor signaling pathway	16/588	113/17913	0.0000	0.0000	16
GO:0048024	regulation of mRNA splicing, via spliceosome	13/588	75/17913	0.0000	0.0000	13
GO:1904872	regulation of telomerase RNA localization to Cajal body	7/588	18/17913	0.0000	0.0000	7
GO:0032210	regulation of telomere maintenance via telomerase	11/588	53/17913	0.0000	0.0000	11
GO:0002576	platelet degranulation	17/588	128/17913	0.0000	0.0000	17
GO:0002768	immune response-regulating cell surface receptor signaling pathway	35/588	434/17913	0.0000	0.0000	35
GO:0070498	interleukin-1-mediated signaling pathway	15/588	101/17913	0.0000	0.0000	15
GO:0032212	positive regulation of telomere maintenance via telomerase	9/588	34/17913	0.0000	0.0000	9
GO:0071453	cellular response to oxygen levels	24/588	237/17913	0.0000	0.0000	24
GO:0009165	nucleotide biosynthetic process	31/588	360/17913	0.0000	0.0000	31
GO:0071478	cellular response to radiation	20/588	173/17913	0.0000	0.0000	20
GO:0043484	regulation of RNA splicing	16/588	115/17913	0.0000	0.0000	16
GO:0052547	regulation of peptidase activity	33/588	398/17913	0.0000	0.0000	33
GO:0002478	antigen processing and presentation of exogenous peptide antigen	20/588	174/17913	0.0000	0.0000	20
GO:0035690	cellular response to drug	31/588	362/17913	0.0000	0.0000	31
GO:1902807	negative regulation of cell cycle G1/S phase transition	17/588	130/17913	0.0000	0.0000	17
GO:0035567	non-canonical Wnt signaling pathway	18/588	145/17913	0.0000	0.0000	18
GO:0071214	cellular response to abiotic stimulus	28/588	310/17913	0.0000	0.0000	28
GO:0104004	cellular response to environmental stimulus	28/588	310/17913	0.0000	0.0000	28
GO:0050851	antigen receptor-mediated signaling pathway	23/588	224/17913	0.0000	0.0000	23
GO:1901699	cellular response to nitrogen compound	44/588	620/17913	0.0000	0.0000	44
GO:0019884	antigen processing and presentation of exogenous antigen	20/588	176/17913	0.0000	0.0000	20
GO:0090670	RNA localization to Cajal body	7/588	19/17913	0.0000	0.0000	7
GO:0090671	telomerase RNA localization to Cajal body	7/588	19/17913	0.0000	0.0000	7
GO:0090672	telomerase RNA localization	7/588	19/17913	0.0000	0.0000	7
GO:0090685	RNA localization to nucleus	7/588	19/17913	0.0000	0.0000	7
GO:1901293	nucleoside phosphate biosynthetic process	31/588	365/17913	0.0000	0.0000	31
GO:0042180	cellular ketone metabolic process	24/588	241/17913	0.0000	0.0000	24
GO:0007004	telomere maintenance via telomerase	12/588	67/17913	0.0000	0.0000	12
GO:0071456	cellular response to hypoxia	22/588	210/17913	0.0000	0.0000	22
GO:0034599	cellular response to oxidative stress	27/588	296/17913	0.0000	0.0000	27
GO:0043900	regulation of multi-organism process	33/588	408/17913	0.0000	0.0001	33
GO:0008284	positive regulation of cell proliferation	58/588	931/17913	0.0000	0.0001	58
GO:0009617	response to bacterium	42/588	588/17913	0.0000	0.0001	42
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	15/588	107/17913	0.0000	0.0001	15
GO:0010720	positive regulation of cell development	39/588	528/17913	0.0000	0.0001	39
GO:0006353	DNA-templated transcription, termination	12/588	69/17913	0.0000	0.0001	12
GO:0045089	positive regulation of innate immune response	31/588	373/17913	0.0000	0.0001	31
GO:0045936	negative regulation of phosphate metabolic process	41/588	573/17913	0.0000	0.0001	41
GO:0043066	negative regulation of apoptotic process	56/588	894/17913	0.0000	0.0001	56
GO:0001736	establishment of planar polarity	16/588	123/17913	0.0000	0.0001	16
GO:0007164	establishment of tissue polarity	16/588	123/17913	0.0000	0.0001	16
GO:0090175	regulation of establishment of planar polarity	15/588	109/17913	0.0000	0.0001	15
GO:0042063	gliogenesis	26/588	285/17913	0.0000	0.0001	26
GO:0010563	negative regulation of phosphorus metabolic process	41/588	574/17913	0.0000	0.0001	41
GO:0051301	cell division	41/588	575/17913	0.0000	0.0001	41
GO:0050769	positive regulation of neurogenesis	35/588	455/17913	0.0000	0.0001	35
GO:0071396	cellular response to lipid	41/588	576/17913	0.0000	0.0001	41
GO:0002573	myeloid leukocyte differentiation	21/588	201/17913	0.0000	0.0001	21
GO:0009887	animal organ morphogenesis	60/588	989/17913	0.0000	0.0001	60
GO:0070661	leukocyte proliferation	25/588	270/17913	0.0000	0.0001	25
GO:0002429	immune response-activating cell surface receptor signaling pathway	32/588	399/17913	0.0000	0.0001	32
GO:0051338	regulation of transferase activity	56/588	903/17913	0.0000	0.0001	56
GO:0036294	cellular response to decreased oxygen levels	22/588	220/17913	0.0000	0.0001	22
GO:0009611	response to wounding	45/588	665/17913	0.0000	0.0001	45
GO:0050792	regulation of viral process	21/588	204/17913	0.0000	0.0001	21
GO:0048002	antigen processing and presentation of peptide antigen	20/588	188/17913	0.0000	0.0001	20
GO:0006091	generation of precursor metabolites and energy	37/588	502/17913	0.0000	0.0001	37
GO:0060341	regulation of cellular localization	54/588	863/17913	0.0000	0.0001	54
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	28/588	328/17913	0.0000	0.0001	28
GO:0006520	cellular amino acid metabolic process	29/588	347/17913	0.0000	0.0001	29
GO:0080135	regulation of cellular response to stress	47/588	713/17913	0.0000	0.0001	47
GO:0043062	extracellular structure organization	31/588	387/17913	0.0000	0.0001	31
GO:0006401	RNA catabolic process	30/588	368/17913	0.0000	0.0001	30
GO:0002757	immune response-activating signal transduction	40/588	567/17913	0.0000	0.0001	40
GO:0010212	response to ionizing radiation	17/588	144/17913	0.0000	0.0001	17
GO:0032496	response to lipopolysaccharide	26/588	295/17913	0.0000	0.0001	26
GO:0043620	regulation of DNA-templated transcription in response to stress	15/588	115/17913	0.0000	0.0001	15
GO:0016579	protein deubiquitination	24/588	260/17913	0.0000	0.0001	24
GO:0006261	DNA-dependent DNA replication	16/588	130/17913	0.0000	0.0001	16
GO:0016999	antibiotic metabolic process	16/588	130/17913	0.0000	0.0001	16
GO:0051050	positive regulation of transport	57/588	942/17913	0.0000	0.0001	57
GO:0002758	innate immune response-activating signal transduction	26/588	298/17913	0.0000	0.0001	26
GO:0071241	cellular response to inorganic substance	20/588	194/17913	0.0000	0.0001	20
GO:0006367	transcription initiation from RNA polymerase II promoter	19/588	178/17913	0.0000	0.0001	19
GO:0006418	tRNA aminoacylation for protein translation	9/588	42/17913	0.0000	0.0002	9
GO:0051236	establishment of RNA localization	19/588	179/17913	0.0000	0.0002	19
GO:0009124	nucleoside monophosphate biosynthetic process	20/588	196/17913	0.0000	0.0002	20
GO:0050852	T cell receptor signaling pathway	19/588	180/17913	0.0000	0.0002	19
GO:0051345	positive regulation of hydrolase activity	45/588	684/17913	0.0000	0.0002	45
GO:0034614	cellular response to reactive oxygen species	18/588	165/17913	0.0000	0.0002	18
GO:0008334	histone mRNA metabolic process	7/588	24/17913	0.0000	0.0002	7
GO:0070199	establishment of protein localization to chromosome	7/588	24/17913	0.0000	0.0002	7
GO:0051962	positive regulation of nervous system development	37/588	519/17913	0.0000	0.0002	37
GO:2000027	regulation of animal organ morphogenesis	23/588	250/17913	0.0000	0.0002	23
GO:0010942	positive regulation of cell death	46/588	710/17913	0.0000	0.0002	46
GO:0044283	small molecule biosynthetic process	47/588	732/17913	0.0000	0.0002	47
GO:0043408	regulation of MAPK cascade	45/588	689/17913	0.0000	0.0002	45
GO:0048511	rhythmic process	25/588	287/17913	0.0000	0.0002	25
GO:0030217	T cell differentiation	22/588	234/17913	0.0000	0.0002	22
GO:0030098	lymphocyte differentiation	27/588	325/17913	0.0000	0.0002	27
GO:0010332	response to gamma radiation	10/588	55/17913	0.0000	0.0002	10
GO:0007623	circadian rhythm	20/588	201/17913	0.0000	0.0002	20
GO:0007420	brain development	45/588	694/17913	0.0000	0.0002	45
GO:0043065	positive regulation of apoptotic process	43/588	652/17913	0.0000	0.0002	43
GO:0070997	neuron death	28/588	347/17913	0.0000	0.0002	28
GO:0055086	nucleobase-containing small molecule metabolic process	47/588	740/17913	0.0000	0.0002	47
GO:0070646	protein modification by small protein removal	24/588	273/17913	0.0000	0.0002	24
GO:0009117	nucleotide metabolic process	43/588	654/17913	0.0000	0.0002	43
GO:0043039	tRNA aminoacylation	9/588	45/17913	0.0000	0.0003	9
GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress	14/588	109/17913	0.0000	0.0003	14
GO:0001738	morphogenesis of a polarized epithelium	16/588	139/17913	0.0000	0.0003	16
GO:1903827	regulation of cellular protein localization	36/588	509/17913	0.0000	0.0003	36
GO:2001251	negative regulation of chromosome organization	15/588	125/17913	0.0000	0.0003	15
GO:0034504	protein localization to nucleus	21/588	223/17913	0.0000	0.0003	21
GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	25/588	295/17913	0.0000	0.0003	25
GO:0043038	amino acid activation	9/588	46/17913	0.0000	0.0003	9
GO:0043068	positive regulation of programmed cell death	43/588	660/17913	0.0000	0.0003	43
GO:0038093	Fc receptor signaling pathway	22/588	241/17913	0.0000	0.0003	22
GO:0030198	extracellular matrix organization	27/588	334/17913	0.0000	0.0003	27
GO:0045787	positive regulation of cell cycle	29/588	373/17913	0.0000	0.0003	29
GO:0006753	nucleoside phosphate metabolic process	43/588	663/17913	0.0000	0.0003	43
GO:0035966	response to topologically incorrect protein	18/588	175/17913	0.0000	0.0004	18
GO:0046651	lymphocyte proliferation	22/588	244/17913	0.0000	0.0004	22
GO:0042326	negative regulation of phosphorylation	33/588	455/17913	0.0000	0.0004	33
GO:0045732	positive regulation of protein catabolic process	19/588	192/17913	0.0000	0.0004	19
GO:0071417	cellular response to organonitrogen compound	38/588	559/17913	0.0000	0.0004	38
GO:0071482	cellular response to light stimulus	14/588	113/17913	0.0000	0.0004	14
GO:0050657	nucleic acid transport	18/588	176/17913	0.0000	0.0004	18
GO:0050658	RNA transport	18/588	176/17913	0.0000	0.0004	18
GO:0044087	regulation of cellular component biogenesis	53/588	891/17913	0.0000	0.0004	53
GO:0072331	signal transduction by p53 class mediator	23/588	264/17913	0.0000	0.0004	23
GO:0032943	mononuclear cell proliferation	22/588	246/17913	0.0000	0.0004	22
GO:1903364	positive regulation of cellular protein catabolic process	15/588	129/17913	0.0000	0.0004	15
GO:2000045	regulation of G1/S transition of mitotic cell cycle	18/588	177/17913	0.0000	0.0004	18
GO:0032069	regulation of nuclease activity	6/588	19/17913	0.0000	0.0004	6
GO:0010565	regulation of cellular ketone metabolic process	18/588	178/17913	0.0000	0.0004	18
GO:1904951	positive regulation of establishment of protein localization	32/588	440/17913	0.0000	0.0004	32
GO:0060322	head development	46/588	738/17913	0.0000	0.0004	46
GO:0000302	response to reactive oxygen species	21/588	230/17913	0.0000	0.0004	21
GO:1903362	regulation of cellular protein catabolic process	21/588	230/17913	0.0000	0.0004	21
GO:0051095	regulation of helicase activity	5/588	12/17913	0.0000	0.0004	5
GO:0006979	response to oxidative stress	32/588	442/17913	0.0000	0.0005	32
GO:0010498	proteasomal protein catabolic process	29/588	382/17913	0.0000	0.0005	29
GO:0032922	circadian regulation of gene expression	10/588	61/17913	0.0000	0.0005	10
GO:0043902	positive regulation of multi-organism process	18/588	180/17913	0.0000	0.0005	18
GO:0001817	regulation of cytokine production	44/588	698/17913	0.0000	0.0005	44
GO:0006275	regulation of DNA replication	13/588	102/17913	0.0000	0.0005	13
GO:0006289	nucleotide-excision repair	13/588	102/17913	0.0000	0.0005	13
GO:1905330	regulation of morphogenesis of an epithelium	18/588	181/17913	0.0000	0.0005	18
GO:0048524	positive regulation of viral process	13/588	103/17913	0.0000	0.0005	13
GO:0001934	positive regulation of protein phosphorylation	53/588	907/17913	0.0000	0.0006	53
GO:0031347	regulation of defense response	52/588	885/17913	0.0000	0.0006	52
GO:0098781	ncRNA transcription	13/588	104/17913	0.0000	0.0006	13
GO:0032508	DNA duplex unwinding	11/588	76/17913	0.0000	0.0006	11
GO:0061136	regulation of proteasomal protein catabolic process	17/588	167/17913	0.0000	0.0006	17
GO:0050764	regulation of phagocytosis	12/588	90/17913	0.0000	0.0006	12
GO:0031349	positive regulation of defense response	35/588	512/17913	0.0000	0.0006	35
GO:0009266	response to temperature stimulus	20/588	219/17913	0.0000	0.0006	20
GO:0052548	regulation of endopeptidase activity	28/588	370/17913	0.0000	0.0006	28
GO:0030099	myeloid cell differentiation	30/588	411/17913	0.0000	0.0007	30
GO:1901214	regulation of neuron death	25/588	313/17913	0.0000	0.0007	25
GO:0006270	DNA replication initiation	7/588	30/17913	0.0000	0.0007	7
GO:0015931	nucleobase-containing compound transport	20/588	221/17913	0.0000	0.0007	20
GO:0071826	ribonucleoprotein complex subunit organization	20/588	221/17913	0.0000	0.0007	20
GO:0006354	DNA-templated transcription, elongation	13/588	106/17913	0.0000	0.0007	13
GO:0008584	male gonad development	15/588	137/17913	0.0000	0.0007	15
GO:0009411	response to UV	15/588	137/17913	0.0000	0.0007	15
GO:0071824	protein-DNA complex subunit organization	21/588	240/17913	0.0000	0.0007	21
GO:0042176	regulation of protein catabolic process	27/588	354/17913	0.0000	0.0007	27
GO:0070317	negative regulation of G0 to G1 transition	8/588	41/17913	0.0000	0.0008	8
GO:0031056	regulation of histone modification	15/588	138/17913	0.0000	0.0008	15
GO:0046546	development of primary male sexual characteristics	15/588	138/17913	0.0000	0.0008	15
GO:0009636	response to toxic substance	34/588	499/17913	0.0001	0.0008	34
GO:1901800	positive regulation of proteasomal protein catabolic process	12/588	93/17913	0.0001	0.0008	12
GO:0006368	transcription elongation from RNA polymerase II promoter	11/588	79/17913	0.0001	0.0008	11
GO:0043549	regulation of kinase activity	48/588	808/17913	0.0001	0.0008	48
GO:0040007	growth	54/588	948/17913	0.0001	0.0009	54
GO:0051347	positive regulation of transferase activity	39/588	609/17913	0.0001	0.0009	39
GO:0001816	cytokine production	46/588	765/17913	0.0001	0.0009	46
GO:0006310	DNA recombination	21/588	244/17913	0.0001	0.0009	21
GO:0033151	V(D)J recombination	5/588	14/17913	0.0001	0.0009	5
GO:0006518	peptide metabolic process	48/588	811/17913	0.0001	0.0009	48
GO:0002440	production of molecular mediator of immune response	18/588	191/17913	0.0001	0.0009	18
GO:0051170	import into nucleus	14/588	125/17913	0.0001	0.0010	14
GO:0022618	ribonucleoprotein complex assembly	19/588	209/17913	0.0001	0.0010	19
GO:0019725	cellular homeostasis	48/588	814/17913	0.0001	0.0010	48
GO:0002285	lymphocyte activation involved in immune response	16/588	158/17913	0.0001	0.0010	16
GO:0065004	protein-DNA complex assembly	19/588	210/17913	0.0001	0.0010	19
GO:0042327	positive regulation of phosphorylation	54/588	955/17913	0.0001	0.0010	54
GO:0097327	response to antineoplastic agent	12/588	96/17913	0.0001	0.0011	12
GO:2000377	regulation of reactive oxygen species metabolic process	18/588	194/17913	0.0001	0.0011	18
GO:1902806	regulation of cell cycle G1/S phase transition	18/588	195/17913	0.0001	0.0012	18
GO:1903312	negative regulation of mRNA metabolic process	10/588	69/17913	0.0001	0.0012	10
GO:0030163	protein catabolic process	47/588	799/17913	0.0001	0.0012	47
GO:0006986	response to unfolded protein	16/588	161/17913	0.0001	0.0012	16
GO:0009416	response to light stimulus	24/588	307/17913	0.0001	0.0012	24
GO:0038061	NIK/NF-kappaB signaling	17/588	179/17913	0.0001	0.0013	17
GO:0045859	regulation of protein kinase activity	44/588	733/17913	0.0001	0.0013	44
GO:0045785	positive regulation of cell adhesion	28/588	388/17913	0.0001	0.0013	28
GO:0046677	response to antibiotic	25/588	328/17913	0.0001	0.0013	25
GO:0042113	B cell activation	19/588	215/17913	0.0001	0.0013	19
GO:0044786	cell cycle DNA replication	9/588	57/17913	0.0001	0.0013	9
GO:0022407	regulation of cell-cell adhesion	28/588	389/17913	0.0001	0.0013	28
GO:0009123	nucleoside monophosphate metabolic process	26/588	349/17913	0.0001	0.0014	26
GO:0070316	regulation of G0 to G1 transition	8/588	45/17913	0.0001	0.0014	8
GO:0016571	histone methylation	14/588	130/17913	0.0001	0.0014	14
GO:1903050	regulation of proteolysis involved in cellular protein catabolic process	18/588	198/17913	0.0001	0.0014	18
GO:0001101	response to acid chemical	25/588	330/17913	0.0001	0.0014	25
GO:0032870	cellular response to hormone stimulus	40/588	647/17913	0.0001	0.0014	40
GO:0044257	cellular protein catabolic process	40/588	648/17913	0.0001	0.0014	40
GO:0002449	lymphocyte mediated immunity	23/588	293/17913	0.0001	0.0015	23
GO:1902275	regulation of chromatin organization	16/588	165/17913	0.0001	0.0016	16
GO:0061614	pri-miRNA transcription by RNA polymerase II	8/588	46/17913	0.0001	0.0016	8
GO:0009991	response to extracellular stimulus	33/588	498/17913	0.0001	0.0016	33
GO:0007569	cell aging	13/588	116/17913	0.0001	0.0016	13
GO:1901998	toxin transport	7/588	35/17913	0.0001	0.0017	7
GO:0006220	pyrimidine nucleotide metabolic process	9/588	59/17913	0.0001	0.0017	9
GO:0048545	response to steroid hormone	27/588	375/17913	0.0001	0.0017	27
GO:0043632	modification-dependent macromolecule catabolic process	34/588	522/17913	0.0001	0.0017	34
GO:0010038	response to metal ion	25/588	335/17913	0.0001	0.0017	25
GO:0006283	transcription-coupled nucleotide-excision repair	10/588	73/17913	0.0001	0.0018	10
GO:0033260	nuclear DNA replication	8/588	47/17913	0.0001	0.0018	8
GO:0045023	G0 to G1 transition	8/588	47/17913	0.0001	0.0018	8
GO:0002562	somatic diversification of immune receptors via germline recombination within a single locus	9/588	60/17913	0.0001	0.0019	9
GO:0016444	somatic cell DNA recombination	9/588	60/17913	0.0001	0.0019	9
GO:0050766	positive regulation of phagocytosis	9/588	60/17913	0.0001	0.0019	9
GO:0006402	mRNA catabolic process	25/588	338/17913	0.0001	0.0019	25
GO:0090263	positive regulation of canonical Wnt signaling pathway	14/588	135/17913	0.0001	0.0019	14
GO:0006479	protein methylation	16/588	169/17913	0.0001	0.0020	16
GO:0008213	protein alkylation	16/588	169/17913	0.0001	0.0020	16
GO:0038095	Fc-epsilon receptor signaling pathway	16/588	169/17913	0.0001	0.0020	16
GO:0032481	positive regulation of type I interferon production	10/588	74/17913	0.0001	0.0020	10
GO:0002009	morphogenesis of an epithelium	34/588	527/17913	0.0001	0.0020	34
GO:0043687	post-translational protein modification	26/588	360/17913	0.0002	0.0021	26
GO:0044089	positive regulation of cellular component biogenesis	33/588	507/17913	0.0002	0.0021	33
GO:0071216	cellular response to biotic stimulus	18/588	206/17913	0.0002	0.0021	18
GO:0060284	regulation of cell development	50/588	893/17913	0.0002	0.0022	50
GO:0097435	supramolecular fiber organization	35/588	553/17913	0.0002	0.0023	35
GO:0006511	ubiquitin-dependent protein catabolic process	33/588	510/17913	0.0002	0.0023	33
GO:0071407	cellular response to organic cyclic compound	34/588	533/17913	0.0002	0.0024	34
GO:0031960	response to corticosteroid	15/588	155/17913	0.0002	0.0024	15
GO:0046390	ribose phosphate biosynthetic process	22/588	284/17913	0.0002	0.0024	22
GO:1903409	reactive oxygen species biosynthetic process	13/588	122/17913	0.0002	0.0024	13
GO:0019058	viral life cycle	24/588	324/17913	0.0002	0.0024	24
GO:0045861	negative regulation of proteolysis	24/588	324/17913	0.0002	0.0024	24
GO:1901652	response to peptide	32/588	491/17913	0.0002	0.0025	32
GO:0050865	regulation of cell activation	34/588	535/17913	0.0002	0.0025	34
GO:0051384	response to glucocorticoid	14/588	139/17913	0.0002	0.0025	14
GO:0050686	negative regulation of mRNA processing	6/588	27/17913	0.0002	0.0026	6
GO:0032479	regulation of type I interferon production	13/588	123/17913	0.0002	0.0026	13
GO:0034644	cellular response to UV	10/588	77/17913	0.0002	0.0026	10
GO:0032873	negative regulation of stress-activated MAPK cascade	8/588	50/17913	0.0002	0.0026	8
GO:0070303	negative regulation of stress-activated protein kinase signaling cascade	8/588	50/17913	0.0002	0.0026	8
GO:0009162	deoxyribonucleoside monophosphate metabolic process	4/588	10/17913	0.0002	0.0026	4
GO:0019941	modification-dependent protein catabolic process	33/588	515/17913	0.0002	0.0026	33
GO:0072594	establishment of protein localization to organelle	30/588	452/17913	0.0002	0.0028	30
GO:0046782	regulation of viral transcription	9/588	64/17913	0.0002	0.0029	9
GO:0072593	reactive oxygen species metabolic process	21/588	269/17913	0.0002	0.0029	21
GO:0006323	DNA packaging	17/588	194/17913	0.0002	0.0029	17
GO:0048146	positive regulation of fibroblast proliferation	8/588	51/17913	0.0002	0.0029	8
GO:0097366	response to bronchodilator	8/588	51/17913	0.0002	0.0029	8
GO:0032606	type I interferon production	13/588	125/17913	0.0002	0.0030	13
GO:0034968	histone lysine methylation	12/588	109/17913	0.0002	0.0030	12
GO:1903052	positive regulation of proteolysis involved in cellular protein catabolic process	12/588	109/17913	0.0002	0.0030	12
GO:0050767	regulation of neurogenesis	44/588	768/17913	0.0002	0.0031	44
GO:0042098	T cell proliferation	16/588	177/17913	0.0002	0.0031	16
GO:0051223	regulation of protein transport	40/588	677/17913	0.0003	0.0031	40
GO:0048709	oligodendrocyte differentiation	11/588	94/17913	0.0003	0.0031	11
GO:0050878	regulation of body fluid levels	32/588	499/17913	0.0003	0.0031	32
GO:0072522	purine-containing compound biosynthetic process	22/588	291/17913	0.0003	0.0031	22
GO:0046661	male sex differentiation	15/588	160/17913	0.0003	0.0031	15
GO:0098727	maintenance of cell number	15/588	160/17913	0.0003	0.0031	15
GO:0032989	cellular component morphogenesis	52/588	960/17913	0.0003	0.0033	52
GO:0051603	proteolysis involved in cellular protein catabolic process	36/588	590/17913	0.0003	0.0034	36
GO:0034976	response to endoplasmic reticulum stress	20/588	254/17913	0.0003	0.0035	20
GO:1902893	regulation of pri-miRNA transcription by RNA polymerase II	7/588	40/17913	0.0003	0.0035	7
GO:0090087	regulation of peptide transport	41/588	706/17913	0.0003	0.0036	41
GO:0009262	deoxyribonucleotide metabolic process	6/588	29/17913	0.0003	0.0036	6
GO:0008406	gonad development	18/588	217/17913	0.0003	0.0036	18
GO:0030968	endoplasmic reticulum unfolded protein response	12/588	112/17913	0.0003	0.0037	12
GO:1903037	regulation of leukocyte cell-cell adhesion	22/588	295/17913	0.0003	0.0037	22
GO:0019042	viral latency	4/588	11/17913	0.0003	0.0038	4
GO:0007599	hemostasis	24/588	336/17913	0.0003	0.0038	24
GO:0042060	wound healing	34/588	550/17913	0.0003	0.0038	34
GO:0002697	regulation of immune effector process	29/588	441/17913	0.0003	0.0038	29
GO:0002200	somatic diversification of immune receptors	9/588	67/17913	0.0003	0.0038	9
GO:0055114	oxidation-reduction process	51/588	944/17913	0.0003	0.0039	51
GO:0006935	chemotaxis	34/588	551/17913	0.0003	0.0039	34
GO:0050434	positive regulation of viral transcription	7/588	41/17913	0.0003	0.0039	7
GO:0051402	neuron apoptotic process	19/588	238/17913	0.0003	0.0040	19
GO:0000902	cell morphogenesis	48/588	874/17913	0.0003	0.0040	48
GO:0006970	response to osmotic stress	10/588	82/17913	0.0003	0.0040	10
GO:0032386	regulation of intracellular transport	27/588	400/17913	0.0003	0.0040	27
GO:1903829	positive regulation of cellular protein localization	23/588	318/17913	0.0004	0.0041	23
GO:0042330	taxis	34/588	553/17913	0.0004	0.0041	34
GO:0071219	cellular response to molecule of bacterial origin	16/588	183/17913	0.0004	0.0042	16
GO:0006304	DNA modification	12/588	114/17913	0.0004	0.0042	12
GO:0002377	immunoglobulin production	11/588	98/17913	0.0004	0.0042	11
GO:0031667	response to nutrient levels	30/588	466/17913	0.0004	0.0042	30
GO:0010543	regulation of platelet activation	6/588	30/17913	0.0004	0.0042	6
GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	6/588	30/17913	0.0004	0.0042	6
GO:0019216	regulation of lipid metabolic process	27/588	402/17913	0.0004	0.0042	27
GO:0002320	lymphoid progenitor cell differentiation	5/588	20/17913	0.0004	0.0044	5
GO:0048872	homeostasis of number of cells	19/588	241/17913	0.0004	0.0045	19
GO:0033077	T cell differentiation in thymus	9/588	69/17913	0.0004	0.0046	9
GO:0033209	tumor necrosis factor-mediated signaling pathway	15/588	167/17913	0.0004	0.0046	15
GO:0071248	cellular response to metal ion	15/588	167/17913	0.0004	0.0046	15
GO:0048608	reproductive structure development	28/588	426/17913	0.0004	0.0046	28
GO:0045137	development of primary sexual characteristics	18/588	223/17913	0.0004	0.0047	18
GO:1901653	cellular response to peptide	25/588	364/17913	0.0004	0.0049	25
GO:0009615	response to virus	23/588	323/17913	0.0004	0.0050	23
GO:0006369	termination of RNA polymerase II transcription	6/588	31/17913	0.0004	0.0050	6
GO:0048871	multicellular organismal homeostasis	30/588	472/17913	0.0005	0.0051	30
GO:0061458	reproductive system development	28/588	429/17913	0.0005	0.0051	28
GO:0031330	negative regulation of cellular catabolic process	19/588	244/17913	0.0005	0.0051	19
GO:1900180	regulation of protein localization to nucleus	12/588	117/17913	0.0005	0.0051	12
GO:0090090	negative regulation of canonical Wnt signaling pathway	15/588	169/17913	0.0005	0.0051	15
GO:0034612	response to tumor necrosis factor	21/588	284/17913	0.0005	0.0052	21
GO:0009156	ribonucleoside monophosphate biosynthetic process	16/588	188/17913	0.0005	0.0053	16
GO:0007063	regulation of sister chromatid cohesion	5/588	21/17913	0.0005	0.0054	5
GO:0030177	positive regulation of Wnt signaling pathway	15/588	170/17913	0.0005	0.0054	15
GO:0035967	cellular response to topologically incorrect protein	13/588	135/17913	0.0005	0.0055	13
GO:0045576	mast cell activation	8/588	57/17913	0.0005	0.0056	8
GO:0072431	signal transduction involved in mitotic G1 DNA damage checkpoint	8/588	57/17913	0.0005	0.0056	8
GO:1902400	intracellular signal transduction involved in G1 DNA damage checkpoint	8/588	57/17913	0.0005	0.0056	8
GO:0071356	cellular response to tumor necrosis factor	20/588	266/17913	0.0005	0.0056	20
GO:0071346	cellular response to interferon-gamma	14/588	153/17913	0.0005	0.0057	14
GO:0030851	granulocyte differentiation	6/588	32/17913	0.0005	0.0057	6
GO:0009267	cellular response to starvation	13/588	136/17913	0.0005	0.0058	13
GO:0007159	leukocyte cell-cell adhesion	23/588	328/17913	0.0006	0.0059	23
GO:0048729	tissue morphogenesis	37/588	635/17913	0.0006	0.0060	37
GO:0001659	temperature homeostasis	15/588	172/17913	0.0006	0.0060	15
GO:0035019	somatic stem cell population maintenance	9/588	72/17913	0.0006	0.0060	9
GO:1901654	response to ketone	16/588	191/17913	0.0006	0.0062	16
GO:0071900	regulation of protein serine/threonine kinase activity	30/588	479/17913	0.0006	0.0062	30
GO:0019079	viral genome replication	12/588	120/17913	0.0006	0.0062	12
GO:0009790	embryo development	51/588	968/17913	0.0006	0.0062	51
GO:0061024	membrane organization	41/588	730/17913	0.0006	0.0063	41
GO:0034341	response to interferon-gamma	15/588	173/17913	0.0006	0.0063	15
GO:0002286	T cell activation involved in immune response	10/588	88/17913	0.0006	0.0064	10
GO:0002456	T cell mediated immunity	10/588	88/17913	0.0006	0.0064	10
GO:0031058	positive regulation of histone modification	10/588	88/17913	0.0006	0.0064	10
GO:0048714	positive regulation of oligodendrocyte differentiation	5/588	22/17913	0.0006	0.0065	5
GO:0007596	blood coagulation	23/588	331/17913	0.0006	0.0065	23
GO:0009410	response to xenobiotic stimulus	20/588	270/17913	0.0006	0.0065	20
GO:0010001	glial cell differentiation	17/588	212/17913	0.0007	0.0067	17
GO:0072413	signal transduction involved in mitotic cell cycle checkpoint	8/588	59/17913	0.0007	0.0067	8
GO:1902402	signal transduction involved in mitotic DNA damage checkpoint	8/588	59/17913	0.0007	0.0067	8
GO:1902403	signal transduction involved in mitotic DNA integrity checkpoint	8/588	59/17913	0.0007	0.0067	8
GO:0043086	negative regulation of catalytic activity	42/588	757/17913	0.0007	0.0067	42
GO:0031668	cellular response to extracellular stimulus	19/588	251/17913	0.0007	0.0067	19
GO:0044728	DNA methylation or demethylation	10/588	89/17913	0.0007	0.0068	10
GO:0060968	regulation of gene silencing	13/588	139/17913	0.0007	0.0068	13
GO:0007006	mitochondrial membrane organization	12/588	122/17913	0.0007	0.0069	12
GO:0018022	peptidyl-lysine methylation	12/588	122/17913	0.0007	0.0069	12
GO:0030193	regulation of blood coagulation	9/588	74/17913	0.0007	0.0070	9
GO:1900182	positive regulation of protein localization to nucleus	9/588	74/17913	0.0007	0.0070	9
GO:0045666	positive regulation of neuron differentiation	24/588	355/17913	0.0007	0.0072	24
GO:0051168	nuclear export	15/588	176/17913	0.0007	0.0072	15
GO:0071222	cellular response to lipopolysaccharide	15/588	176/17913	0.0007	0.0072	15
GO:0043200	response to amino acid	11/588	106/17913	0.0007	0.0073	11
GO:0009408	response to heat	14/588	158/17913	0.0007	0.0073	14
GO:0019827	stem cell population maintenance	14/588	158/17913	0.0007	0.0073	14
GO:1903039	positive regulation of leukocyte cell-cell adhesion	17/588	214/17913	0.0007	0.0073	17
GO:0034620	cellular response to unfolded protein	12/588	123/17913	0.0007	0.0073	12
GO:0006412	translation	38/588	668/17913	0.0007	0.0074	38
GO:1900046	regulation of hemostasis	9/588	75/17913	0.0008	0.0076	9
GO:0045807	positive regulation of endocytosis	13/588	141/17913	0.0008	0.0076	13
GO:0007064	mitotic sister chromatid cohesion	5/588	23/17913	0.0008	0.0076	5
GO:2000637	positive regulation of gene silencing by miRNA	5/588	23/17913	0.0008	0.0076	5
GO:0043043	peptide biosynthetic process	39/588	693/17913	0.0008	0.0077	39
GO:0048589	developmental growth	36/588	624/17913	0.0008	0.0078	36
GO:0050817	coagulation	23/588	337/17913	0.0008	0.0078	23
GO:0035821	modification of morphology or physiology of other organism	14/588	160/17913	0.0008	0.0081	14
GO:0042692	muscle cell differentiation	24/588	359/17913	0.0008	0.0081	24
GO:0014015	positive regulation of gliogenesis	9/588	76/17913	0.0008	0.0082	9
GO:0001819	positive regulation of cytokine production	28/588	446/17913	0.0008	0.0083	28
GO:2001022	positive regulation of response to DNA damage stimulus	10/588	92/17913	0.0009	0.0084	10
GO:0007339	binding of sperm to zona pellucida	6/588	35/17913	0.0009	0.0085	6
GO:0045740	positive regulation of DNA replication	6/588	35/17913	0.0009	0.0085	6
GO:0010885	regulation of cholesterol storage	4/588	14/17913	0.0009	0.0086	4
GO:0010952	positive regulation of peptidase activity	15/588	180/17913	0.0009	0.0087	15
GO:0031098	stress-activated protein kinase signaling cascade	20/588	278/17913	0.0009	0.0087	20
GO:0002064	epithelial cell development	16/588	199/17913	0.0009	0.0087	16
GO:0032648	regulation of interferon-beta production	7/588	48/17913	0.0009	0.0087	7
GO:0051972	regulation of telomerase activity	7/588	48/17913	0.0009	0.0087	7
GO:0061647	histone H3-K9 modification	7/588	48/17913	0.0009	0.0087	7
GO:1903727	positive regulation of phospholipid metabolic process	7/588	48/17913	0.0009	0.0087	7
GO:0042542	response to hydrogen peroxide	13/588	144/17913	0.0009	0.0089	13
GO:0098609	cell-cell adhesion	42/588	771/17913	0.0009	0.0089	42
GO:0009260	ribonucleotide biosynthetic process	20/588	279/17913	0.0009	0.0090	20
GO:0060148	positive regulation of posttranscriptional gene silencing	5/588	24/17913	0.0009	0.0090	5
GO:0006164	purine nucleotide biosynthetic process	20/588	280/17913	0.0010	0.0094	20
GO:0002262	myeloid cell homeostasis	13/588	145/17913	0.0010	0.0094	13
GO:2001020	regulation of response to DNA damage stimulus	16/588	201/17913	0.0010	0.0095	16
GO:0043901	negative regulation of multi-organism process	15/588	182/17913	0.0010	0.0095	15
GO:1903708	positive regulation of hemopoiesis	15/588	182/17913	0.0010	0.0095	15
GO:0033674	positive regulation of kinase activity	32/588	541/17913	0.0010	0.0095	32
GO:0031571	mitotic G1 DNA damage checkpoint	8/588	63/17913	0.0010	0.0095	8
GO:0036498	IRE1-mediated unfolded protein response	8/588	63/17913	0.0010	0.0095	8
GO:0044819	mitotic G1/S transition checkpoint	8/588	63/17913	0.0010	0.0095	8
GO:0007229	integrin-mediated signaling pathway	10/588	94/17913	0.0010	0.0095	10
GO:1990823	response to leukemia inhibitory factor	10/588	94/17913	0.0010	0.0095	10
GO:1990830	cellular response to leukemia inhibitory factor	10/588	94/17913	0.0010	0.0095	10
GO:0051973	positive regulation of telomerase activity	6/588	36/17913	0.0010	0.0095	6
GO:0097237	cellular response to toxic substance	18/588	241/17913	0.0010	0.0097	18
GO:1904019	epithelial cell apoptotic process	11/588	111/17913	0.0011	0.0098	11
GO:0043254	regulation of protein complex assembly	26/588	409/17913	0.0011	0.0099	26

C (525 terms)

ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	Count
GO:0002366	leukocyte activation involved in immune response	59/300	684/17913	0.0000	0.0000	59
GO:0002263	cell activation involved in immune response	59/300	688/17913	0.0000	0.0000	59
GO:0002274	myeloid leukocyte activation	56/300	652/17913	0.0000	0.0000	56
GO:0036230	granulocyte activation	48/300	506/17913	0.0000	0.0000	48
GO:0042119	neutrophil activation	47/300	499/17913	0.0000	0.0000	47
GO:0006887	exocytosis	61/300	862/17913	0.0000	0.0000	61
GO:0043299	leukocyte degranulation	48/300	532/17913	0.0000	0.0000	48
GO:0043312	neutrophil degranulation	45/300	485/17913	0.0000	0.0000	45
GO:0045055	regulated exocytosis	56/300	768/17913	0.0000	0.0000	56
GO:0002283	neutrophil activation involved in immune response	45/300	488/17913	0.0000	0.0000	45
GO:0002275	myeloid cell activation involved in immune response	47/300	542/17913	0.0000	0.0000	47
GO:0002446	neutrophil mediated immunity	45/300	499/17913	0.0000	0.0000	45
GO:0002444	myeloid leukocyte mediated immunity	47/300	549/17913	0.0000	0.0000	47
GO:0002443	leukocyte mediated immunity	55/300	814/17913	0.0000	0.0000	55
GO:0019221	cytokine-mediated signaling pathway	46/300	764/17913	0.0000	0.0000	46
GO:0097190	apoptotic signaling pathway	37/300	579/17913	0.0000	0.0000	37
GO:0050865	regulation of cell activation	34/300	535/17913	0.0000	0.0000	34
GO:2001233	regulation of apoptotic signaling pathway	29/300	397/17913	0.0000	0.0000	29
GO:0043066	negative regulation of apoptotic process	45/300	894/17913	0.0000	0.0000	45
GO:0043069	negative regulation of programmed cell death	45/300	916/17913	0.0000	0.0000	45
GO:0001816	cytokine production	40/300	765/17913	0.0000	0.0000	40
GO:0002694	regulation of leukocyte activation	31/300	492/17913	0.0000	0.0000	31
GO:0002520	immune system development	44/300	938/17913	0.0000	0.0000	44
GO:0014070	response to organic cyclic compound	42/300	879/17913	0.0000	0.0000	42
GO:0050867	positive regulation of cell activation	24/300	319/17913	0.0000	0.0000	24
GO:0032870	cellular response to hormone stimulus	35/300	647/17913	0.0000	0.0000	35
GO:0048534	hematopoietic or lymphoid organ development	42/300	890/17913	0.0000	0.0000	42
GO:0001817	regulation of cytokine production	36/300	698/17913	0.0000	0.0000	36
GO:0030097	hemopoiesis	40/300	847/17913	0.0000	0.0000	40
GO:0010942	positive regulation of cell death	36/300	710/17913	0.0000	0.0000	36
GO:0019725	cellular homeostasis	39/300	814/17913	0.0000	0.0000	39
GO:0001818	negative regulation of cytokine production	22/300	290/17913	0.0000	0.0000	22
GO:0043065	positive regulation of apoptotic process	34/300	652/17913	0.0000	0.0000	34
GO:0010035	response to inorganic substance	30/300	528/17913	0.0000	0.0000	30
GO:0043068	positive regulation of programmed cell death	34/300	660/17913	0.0000	0.0000	34
GO:0002285	lymphocyte activation involved in immune response	16/300	158/17913	0.0000	0.0000	16
GO:0009725	response to hormone	41/300	920/17913	0.0000	0.0000	41
GO:0002696	positive regulation of leukocyte activation	22/300	305/17913	0.0000	0.0000	22
GO:0044403	symbiont process	40/300	884/17913	0.0000	0.0000	40
GO:0042493	response to drug	42/300	958/17913	0.0000	0.0000	42
GO:0002700	regulation of production of molecular mediator of immune response	15/300	138/17913	0.0000	0.0000	15
GO:0044419	interspecies interaction between organisms	41/300	928/17913	0.0000	0.0000	41
GO:0046916	cellular transition metal ion homeostasis	12/300	83/17913	0.0000	0.0000	12
GO:0030003	cellular cation homeostasis	29/300	518/17913	0.0000	0.0000	29
GO:0070997	neuron death	23/300	347/17913	0.0000	0.0000	23
GO:0002440	production of molecular mediator of immune response	17/300	191/17913	0.0000	0.0000	17
GO:0006873	cellular ion homeostasis	29/300	531/17913	0.0000	0.0000	29
GO:0046649	lymphocyte activation	32/300	630/17913	0.0000	0.0000	32
GO:0000165	MAPK cascade	39/300	882/17913	0.0000	0.0000	39
GO:0023014	signal transduction by protein phosphorylation	39/300	886/17913	0.0000	0.0000	39
GO:2001234	negative regulation of apoptotic signaling pathway	18/300	223/17913	0.0000	0.0000	18
GO:0002521	leukocyte differentiation	27/300	485/17913	0.0000	0.0000	27
GO:0010038	response to metal ion	22/300	335/17913	0.0000	0.0000	22
GO:0051050	positive regulation of transport	40/300	942/17913	0.0000	0.0000	40
GO:0055080	cation homeostasis	30/300	588/17913	0.0000	0.0000	30
GO:0040007	growth	40/300	948/17913	0.0000	0.0000	40
GO:0030155	regulation of cell adhesion	32/300	659/17913	0.0000	0.0000	32
GO:1901214	regulation of neuron death	21/300	313/17913	0.0000	0.0000	21
GO:0051249	regulation of lymphocyte activation	24/300	401/17913	0.0000	0.0000	24
GO:0055082	cellular chemical homeostasis	32/300	666/17913	0.0000	0.0000	32
GO:0050778	positive regulation of immune response	36/300	809/17913	0.0000	0.0000	36
GO:1903706	regulation of hemopoiesis	26/300	468/17913	0.0000	0.0000	26
GO:0098771	inorganic ion homeostasis	30/300	600/17913	0.0000	0.0000	30
GO:0007568	aging	21/300	318/17913	0.0000	0.0000	21
GO:1903047	mitotic cell cycle process	36/300	816/17913	0.0000	0.0000	36
GO:0030099	myeloid cell differentiation	24/300	411/17913	0.0000	0.0000	24
GO:0010243	response to organonitrogen compound	39/300	932/17913	0.0000	0.0000	39
GO:0000278	mitotic cell cycle	39/300	934/17913	0.0000	0.0000	39
GO:0016032	viral process	36/300	822/17913	0.0000	0.0000	36
GO:0007584	response to nutrient	17/300	215/17913	0.0000	0.0000	17
GO:0051186	cofactor metabolic process	28/300	543/17913	0.0000	0.0000	28
GO:0007159	leukocyte cell-cell adhesion	21/300	328/17913	0.0000	0.0000	21
GO:0055076	transition metal ion homeostasis	12/300	105/17913	0.0000	0.0000	12
GO:0002576	platelet degranulation	13/300	128/17913	0.0000	0.0000	13
GO:0033993	response to lipid	37/300	884/17913	0.0000	0.0000	37
GO:0051098	regulation of binding	22/300	368/17913	0.0000	0.0000	22
GO:0071222	cellular response to lipopolysaccharide	15/300	176/17913	0.0000	0.0000	15
GO:0050801	ion homeostasis	31/300	669/17913	0.0000	0.0000	31
GO:0050900	leukocyte migration	25/300	467/17913	0.0000	0.0000	25
GO:0071219	cellular response to molecule of bacterial origin	15/300	183/17913	0.0000	0.0000	15
GO:0002683	negative regulation of immune system process	24/300	451/17913	0.0000	0.0000	24
GO:0007346	regulation of mitotic cell cycle	29/300	622/17913	0.0000	0.0000	29
GO:0000122	negative regulation of transcription by RNA polymerase II	32/300	735/17913	0.0000	0.0000	32
GO:1905477	positive regulation of protein localization to membrane	12/300	120/17913	0.0000	0.0000	12
GO:0002637	regulation of immunoglobulin production	9/300	62/17913	0.0000	0.0000	9
GO:0008284	positive regulation of cell proliferation	37/300	931/17913	0.0000	0.0000	37
GO:0040008	regulation of growth	30/300	668/17913	0.0000	0.0000	30
GO:1901990	regulation of mitotic cell cycle phase transition	23/300	428/17913	0.0000	0.0000	23
GO:0045087	innate immune response	36/300	893/17913	0.0000	0.0000	36
GO:2000379	positive regulation of reactive oxygen species metabolic process	11/300	101/17913	0.0000	0.0001	11
GO:0055094	response to lipoprotein particle	7/300	33/17913	0.0000	0.0001	7
GO:0097193	intrinsic apoptotic signaling pathway	18/300	277/17913	0.0000	0.0001	18
GO:0044772	mitotic cell cycle phase transition	27/300	565/17913	0.0000	0.0001	27
GO:0055065	metal ion homeostasis	26/300	531/17913	0.0000	0.0001	26
GO:2000116	regulation of cysteine-type endopeptidase activity	16/300	222/17913	0.0000	0.0001	16
GO:1901987	regulation of cell cycle phase transition	24/300	464/17913	0.0000	0.0001	24
GO:0009991	response to extracellular stimulus	25/300	498/17913	0.0000	0.0001	25
GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	15/300	196/17913	0.0000	0.0001	15
GO:0006954	inflammatory response	33/300	784/17913	0.0000	0.0001	33
GO:0045637	regulation of myeloid cell differentiation	17/300	250/17913	0.0000	0.0001	17
GO:0010507	negative regulation of autophagy	10/300	83/17913	0.0000	0.0001	10
GO:0006875	cellular metal ion homeostasis	24/300	467/17913	0.0000	0.0001	24
GO:0043302	positive regulation of leukocyte degranulation	6/300	22/17913	0.0000	0.0001	6
GO:0051338	regulation of transferase activity	36/300	903/17913	0.0000	0.0001	36
GO:0002699	positive regulation of immune effector process	15/300	198/17913	0.0000	0.0001	15
GO:0044770	cell cycle phase transition	28/300	609/17913	0.0000	0.0001	28
GO:0006914	autophagy	24/300	471/17913	0.0000	0.0001	24
GO:0061919	process utilizing autophagic mechanism	24/300	471/17913	0.0000	0.0001	24
GO:0071402	cellular response to lipoprotein particle stimulus	7/300	35/17913	0.0000	0.0001	7
GO:0002573	myeloid leukocyte differentiation	15/300	201/17913	0.0000	0.0001	15
GO:2001236	regulation of extrinsic apoptotic signaling pathway	13/300	151/17913	0.0000	0.0001	13
GO:0006979	response to oxidative stress	23/300	442/17913	0.0000	0.0001	23
GO:0051251	positive regulation of lymphocyte activation	17/300	258/17913	0.0000	0.0001	17
GO:0009895	negative regulation of catabolic process	18/300	288/17913	0.0000	0.0001	18
GO:0001819	positive regulation of cytokine production	23/300	446/17913	0.0000	0.0001	23
GO:0071216	cellular response to biotic stimulus	15/300	206/17913	0.0000	0.0001	15
GO:1900407	regulation of cellular response to oxidative stress	10/300	88/17913	0.0000	0.0001	10
GO:1901215	negative regulation of neuron death	15/300	207/17913	0.0000	0.0001	15
GO:0098609	cell-cell adhesion	32/300	771/17913	0.0000	0.0001	32
GO:1903708	positive regulation of hemopoiesis	14/300	182/17913	0.0000	0.0001	14
GO:0045785	positive regulation of cell adhesion	21/300	388/17913	0.0000	0.0001	21
GO:0032496	response to lipopolysaccharide	18/300	295/17913	0.0000	0.0001	18
GO:0070482	response to oxygen levels	21/300	389/17913	0.0000	0.0001	21
GO:0034599	cellular response to oxidative stress	18/300	296/17913	0.0000	0.0001	18
GO:1901652	response to peptide	24/300	491/17913	0.0000	0.0001	24
GO:0099132	ATP hydrolysis coupled cation transmembrane transport	8/300	54/17913	0.0000	0.0001	8
GO:0071901	negative regulation of protein serine/threonine kinase activity	12/300	136/17913	0.0000	0.0001	12
GO:0002685	regulation of leukocyte migration	14/300	186/17913	0.0000	0.0001	14
GO:0070661	leukocyte proliferation	17/300	270/17913	0.0000	0.0001	17
GO:1903039	positive regulation of leukocyte cell-cell adhesion	15/300	214/17913	0.0000	0.0001	15
GO:0051707	response to other organism	35/300	903/17913	0.0000	0.0001	35
GO:0043207	response to external biotic stimulus	35/300	905/17913	0.0000	0.0001	35
GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	6/300	26/17913	0.0000	0.0001	6
GO:0002764	immune response-regulating signaling pathway	27/300	603/17913	0.0000	0.0001	27
GO:0031330	negative regulation of cellular catabolic process	16/300	244/17913	0.0000	0.0001	16
GO:0071407	cellular response to organic cyclic compound	25/300	533/17913	0.0000	0.0001	25
GO:0030316	osteoclast differentiation	10/300	94/17913	0.0000	0.0001	10
GO:0006826	iron ion transport	8/300	56/17913	0.0000	0.0001	8
GO:0032943	mononuclear cell proliferation	16/300	246/17913	0.0000	0.0001	16
GO:0043086	negative regulation of catalytic activity	31/300	757/17913	0.0000	0.0001	31
GO:0052548	regulation of endopeptidase activity	20/300	370/17913	0.0000	0.0001	20
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	7/300	41/17913	0.0000	0.0002	7
GO:0071396	cellular response to lipid	26/300	576/17913	0.0000	0.0002	26
GO:0043434	response to peptide hormone	21/300	404/17913	0.0000	0.0002	21
GO:0002237	response to molecule of bacterial origin	18/300	309/17913	0.0000	0.0002	18
GO:1902882	regulation of response to oxidative stress	10/300	97/17913	0.0000	0.0002	10
GO:0045089	positive regulation of innate immune response	20/300	373/17913	0.0000	0.0002	20
GO:1902107	positive regulation of leukocyte differentiation	12/300	143/17913	0.0000	0.0002	12
GO:0045088	regulation of innate immune response	22/300	440/17913	0.0000	0.0002	22
GO:0002697	regulation of immune effector process	22/300	441/17913	0.0000	0.0002	22
GO:0002377	immunoglobulin production	10/300	98/17913	0.0000	0.0002	10
GO:0034394	protein localization to cell surface	8/300	59/17913	0.0000	0.0002	8
GO:0010506	regulation of autophagy	18/300	314/17913	0.0000	0.0002	18
GO:0071900	regulation of protein serine/threonine kinase activity	23/300	479/17913	0.0000	0.0002	23
GO:0043300	regulation of leukocyte degranulation	7/300	43/17913	0.0000	0.0002	7
GO:0032930	positive regulation of superoxide anion generation	5/300	17/17913	0.0000	0.0002	5
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	10/300	100/17913	0.0000	0.0002	10
GO:0009611	response to wounding	28/300	665/17913	0.0000	0.0002	28
GO:0009607	response to biotic stimulus	35/300	938/17913	0.0000	0.0002	35
GO:0031589	cell-substrate adhesion	18/300	322/17913	0.0000	0.0002	18
GO:0071887	leukocyte apoptotic process	10/300	103/17913	0.0000	0.0002	10
GO:0043062	extracellular structure organization	20/300	387/17913	0.0000	0.0003	20
GO:0045921	positive regulation of exocytosis	9/300	82/17913	0.0000	0.0003	9
GO:2001235	positive regulation of apoptotic signaling pathway	13/300	178/17913	0.0000	0.0003	13
GO:0006897	endocytosis	28/300	675/17913	0.0000	0.0003	28
GO:0031400	negative regulation of protein modification process	26/300	602/17913	0.0000	0.0003	26
GO:1903037	regulation of leukocyte cell-cell adhesion	17/300	295/17913	0.0000	0.0003	17
GO:0009894	regulation of catabolic process	34/300	916/17913	0.0000	0.0003	34
GO:0051090	regulation of DNA-binding transcription factor activity	21/300	429/17913	0.0000	0.0003	21
GO:0051402	neuron apoptotic process	15/300	238/17913	0.0000	0.0003	15
GO:0050878	regulation of body fluid levels	23/300	499/17913	0.0000	0.0003	23
GO:0043523	regulation of neuron apoptotic process	14/300	210/17913	0.0000	0.0003	14
GO:0072593	reactive oxygen species metabolic process	16/300	269/17913	0.0000	0.0003	16
GO:0016049	cell growth	22/300	466/17913	0.0000	0.0003	22
GO:0031667	response to nutrient levels	22/300	466/17913	0.0000	0.0003	22
GO:0052547	regulation of peptidase activity	20/300	398/17913	0.0000	0.0003	20
GO:0051051	negative regulation of transport	23/300	502/17913	0.0000	0.0003	23
GO:0010564	regulation of cell cycle process	30/300	764/17913	0.0000	0.0004	30
GO:1903307	positive regulation of regulated secretory pathway	7/300	48/17913	0.0000	0.0004	7
GO:0002703	regulation of leukocyte mediated immunity	13/300	185/17913	0.0000	0.0004	13
GO:0097191	extrinsic apoptotic signaling pathway	14/300	213/17913	0.0000	0.0004	14
GO:0033002	muscle cell proliferation	15/300	243/17913	0.0000	0.0004	15
GO:0070663	regulation of leukocyte proliferation	14/300	214/17913	0.0000	0.0004	14
GO:0009117	nucleotide metabolic process	27/300	654/17913	0.0000	0.0004	27
GO:0046651	lymphocyte proliferation	15/300	244/17913	0.0000	0.0004	15
GO:0042113	B cell activation	14/300	215/17913	0.0000	0.0004	14
GO:0002822	regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	11/300	135/17913	0.0000	0.0004	11
GO:1902532	negative regulation of intracellular signal transduction	24/300	550/17913	0.0000	0.0005	24
GO:2001242	regulation of intrinsic apoptotic signaling pathway	12/300	163/17913	0.0000	0.0005	12
GO:0006753	nucleoside phosphate metabolic process	27/300	663/17913	0.0000	0.0005	27
GO:0032928	regulation of superoxide anion generation	5/300	21/17913	0.0000	0.0005	5
GO:0070848	response to growth factor	28/300	704/17913	0.0000	0.0005	28
GO:0002701	negative regulation of production of molecular mediator of immune response	6/300	35/17913	0.0000	0.0005	6
GO:0090322	regulation of superoxide metabolic process	6/300	35/17913	0.0000	0.0005	6
GO:0051272	positive regulation of cellular component movement	24/300	555/17913	0.0000	0.0005	24
GO:0022409	positive regulation of cell-cell adhesion	15/300	251/17913	0.0000	0.0005	15
GO:0045628	regulation of T-helper 2 cell differentiation	4/300	11/17913	0.0000	0.0005	4
GO:0036473	cell death in response to oxidative stress	9/300	92/17913	0.0000	0.0005	9
GO:0002312	B cell activation involved in immune response	8/300	71/17913	0.0000	0.0005	8
GO:0042100	B cell proliferation	8/300	71/17913	0.0000	0.0005	8
GO:0007249	I-kappaB kinase/NF-kappaB signaling	15/300	253/17913	0.0000	0.0006	15
GO:0002702	positive regulation of production of molecular mediator of immune response	9/300	93/17913	0.0000	0.0006	9
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	14/300	224/17913	0.0000	0.0006	14
GO:0098657	import into cell	29/300	751/17913	0.0000	0.0006	29
GO:0010742	macrophage derived foam cell differentiation	6/300	36/17913	0.0000	0.0006	6
GO:0015682	ferric iron transport	6/300	36/17913	0.0000	0.0006	6
GO:0033572	transferrin transport	6/300	36/17913	0.0000	0.0006	6
GO:0072512	trivalent inorganic cation transport	6/300	36/17913	0.0000	0.0006	6
GO:0090077	foam cell differentiation	6/300	36/17913	0.0000	0.0006	6
GO:0002705	positive regulation of leukocyte mediated immunity	10/300	117/17913	0.0000	0.0006	10
GO:0002761	regulation of myeloid leukocyte differentiation	10/300	117/17913	0.0000	0.0006	10
GO:0002218	activation of innate immune response	17/300	319/17913	0.0000	0.0006	17
GO:0050870	positive regulation of T cell activation	13/300	198/17913	0.0000	0.0006	13
GO:0051046	regulation of secretion	29/300	757/17913	0.0000	0.0006	29
GO:0002757	immune response-activating signal transduction	24/300	567/17913	0.0000	0.0007	24
GO:0022407	regulation of cell-cell adhesion	19/300	389/17913	0.0000	0.0007	19
GO:0030001	metal ion transport	30/300	800/17913	0.0000	0.0007	30
GO:0071404	cellular response to low-density lipoprotein particle stimulus	5/300	23/17913	0.0000	0.0007	5
GO:0032944	regulation of mononuclear cell proliferation	13/300	200/17913	0.0000	0.0007	13
GO:0048660	regulation of smooth muscle cell proliferation	12/300	172/17913	0.0000	0.0007	12
GO:0042089	cytokine biosynthetic process	10/300	120/17913	0.0000	0.0007	10
GO:0051101	regulation of DNA binding	10/300	120/17913	0.0000	0.0007	10
GO:0071888	macrophage apoptotic process	4/300	12/17913	0.0000	0.0007	4
GO:2000145	regulation of cell motility	34/300	966/17913	0.0000	0.0007	34
GO:1903201	regulation of oxidative stress-induced cell death	8/300	75/17913	0.0000	0.0007	8
GO:0031347	regulation of defense response	32/300	885/17913	0.0000	0.0007	32
GO:0042107	cytokine metabolic process	10/300	121/17913	0.0000	0.0007	10
GO:0007167	enzyme linked receptor protein signaling pathway	34/300	968/17913	0.0000	0.0007	34
GO:0048659	smooth muscle cell proliferation	12/300	174/17913	0.0000	0.0007	12
GO:0043903	regulation of symbiosis, encompassing mutualism through parasitism	14/300	232/17913	0.0000	0.0008	14
GO:0043408	regulation of MAPK cascade	27/300	689/17913	0.0000	0.0008	27
GO:0043549	regulation of kinase activity	30/300	808/17913	0.0000	0.0008	30
GO:0071375	cellular response to peptide hormone stimulus	16/300	297/17913	0.0000	0.0008	16
GO:0006879	cellular iron ion homeostasis	7/300	57/17913	0.0000	0.0009	7
GO:0045859	regulation of protein kinase activity	28/300	733/17913	0.0000	0.0009	28
GO:0043112	receptor metabolic process	12/300	177/17913	0.0000	0.0009	12
GO:1901653	cellular response to peptide	18/300	364/17913	0.0000	0.0009	18
GO:0002758	innate immune response-activating signal transduction	16/300	298/17913	0.0000	0.0009	16
GO:0002819	regulation of adaptive immune response	11/300	150/17913	0.0000	0.0009	11
GO:0010959	regulation of metal ion transport	18/300	365/17913	0.0000	0.0009	18
GO:0036293	response to decreased oxygen levels	18/300	365/17913	0.0000	0.0009	18
GO:1902105	regulation of leukocyte differentiation	15/300	267/17913	0.0000	0.0009	15
GO:0051170	import into nucleus	10/300	125/17913	0.0000	0.0009	10
GO:0006732	coenzyme metabolic process	18/300	366/17913	0.0000	0.0009	18
GO:0048661	positive regulation of smooth muscle cell proliferation	9/300	101/17913	0.0000	0.0009	9
GO:1903827	regulation of cellular protein localization	22/300	509/17913	0.0001	0.0009	22
GO:0002719	negative regulation of cytokine production involved in immune response	5/300	25/17913	0.0001	0.0009	5
GO:0015991	ATP hydrolysis coupled proton transport	5/300	25/17913	0.0001	0.0009	5
GO:0030198	extracellular matrix organization	17/300	334/17913	0.0001	0.0009	17
GO:0055086	nucleobase-containing small molecule metabolic process	28/300	740/17913	0.0001	0.0009	28
GO:0031623	receptor internalization	9/300	102/17913	0.0001	0.0010	9
GO:0060341	regulation of cellular localization	31/300	863/17913	0.0001	0.0010	31
GO:0071346	cellular response to interferon-gamma	11/300	153/17913	0.0001	0.0010	11
GO:0031349	positive regulation of defense response	22/300	512/17913	0.0001	0.0010	22
GO:0007599	hemostasis	17/300	336/17913	0.0001	0.0010	17
GO:0051403	stress-activated MAPK cascade	15/300	271/17913	0.0001	0.0010	15
GO:1903530	regulation of secretion by cell	27/300	703/17913	0.0001	0.0010	27
GO:1905475	regulation of protein localization to membrane	12/300	181/17913	0.0001	0.0010	12
GO:0030334	regulation of cell migration	32/300	906/17913	0.0001	0.0010	32
GO:0009617	response to bacterium	24/300	588/17913	0.0001	0.0010	24
GO:0043536	positive regulation of blood vessel endothelial cell migration	8/300	80/17913	0.0001	0.0010	8
GO:0006911	phagocytosis, engulfment	6/300	41/17913	0.0001	0.0010	6
GO:0051348	negative regulation of transferase activity	15/300	272/17913	0.0001	0.0010	15
GO:0006606	protein import into nucleus	9/300	103/17913	0.0001	0.0010	9
GO:0048872	homeostasis of number of cells	14/300	241/17913	0.0001	0.0010	14
GO:0043534	blood vessel endothelial cell migration	12/300	182/17913	0.0001	0.0010	12
GO:0042110	T cell activation	20/300	443/17913	0.0001	0.0010	20
GO:0030335	positive regulation of cell migration	22/300	516/17913	0.0001	0.0010	22
GO:0002562	somatic diversification of immune receptors via germline recombination within a single locus	7/300	60/17913	0.0001	0.0010	7
GO:0016444	somatic cell DNA recombination	7/300	60/17913	0.0001	0.0010	7
GO:0060759	regulation of response to cytokine stimulus	12/300	183/17913	0.0001	0.0010	12
GO:0015988	energy coupled proton transmembrane transport, against electrochemical gradient	5/300	26/17913	0.0001	0.0010	5
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	26/300	669/17913	0.0001	0.0010	26
GO:0050863	regulation of T cell activation	16/300	307/17913	0.0001	0.0011	16
GO:0033673	negative regulation of kinase activity	14/300	244/17913	0.0001	0.0011	14
GO:0045926	negative regulation of growth	14/300	244/17913	0.0001	0.0011	14
GO:0051924	regulation of calcium ion transport	14/300	244/17913	0.0001	0.0011	14
GO:0006974	cellular response to DNA damage stimulus	29/300	791/17913	0.0001	0.0011	29
GO:0002523	leukocyte migration involved in inflammatory response	4/300	14/17913	0.0001	0.0011	4
GO:0045064	T-helper 2 cell differentiation	4/300	14/17913	0.0001	0.0011	4
GO:0010389	regulation of G2/M transition of mitotic cell cycle	12/300	185/17913	0.0001	0.0011	12
GO:0080135	regulation of cellular response to stress	27/300	713/17913	0.0001	0.0011	27
GO:0071363	cellular response to growth factor stimulus	26/300	674/17913	0.0001	0.0011	26
GO:0031098	stress-activated protein kinase signaling cascade	15/300	278/17913	0.0001	0.0012	15
GO:0002718	regulation of cytokine production involved in immune response	8/300	83/17913	0.0001	0.0012	8
GO:0099131	ATP hydrolysis coupled ion transmembrane transport	5/300	27/17913	0.0001	0.0012	5
GO:0070542	response to fatty acid	8/300	85/17913	0.0001	0.0014	8
GO:0002467	germinal center formation	4/300	15/17913	0.0001	0.0014	4
GO:0090662	ATP hydrolysis coupled transmembrane transport	5/300	28/17913	0.0001	0.0014	5
GO:0051100	negative regulation of binding	11/300	162/17913	0.0001	0.0014	11
GO:0002253	activation of immune response	25/300	647/17913	0.0001	0.0015	25
GO:0032602	chemokine production	8/300	86/17913	0.0001	0.0015	8
GO:0048145	regulation of fibroblast proliferation	8/300	86/17913	0.0001	0.0015	8
GO:0040017	positive regulation of locomotion	23/300	570/17913	0.0001	0.0015	23
GO:0042035	regulation of cytokine biosynthetic process	9/300	110/17913	0.0001	0.0015	9
GO:0050864	regulation of B cell activation	9/300	110/17913	0.0001	0.0015	9
GO:0071675	regulation of mononuclear cell migration	6/300	45/17913	0.0001	0.0015	6
GO:0006469	negative regulation of protein kinase activity	13/300	222/17913	0.0001	0.0015	13
GO:0051235	maintenance of location	15/300	286/17913	0.0001	0.0015	15
GO:0071466	cellular response to xenobiotic stimulus	11/300	164/17913	0.0001	0.0015	11
GO:0048144	fibroblast proliferation	8/300	87/17913	0.0001	0.0016	8
GO:0045936	negative regulation of phosphate metabolic process	23/300	573/17913	0.0001	0.0016	23
GO:0009411	response to UV	10/300	137/17913	0.0001	0.0016	10
GO:0032880	regulation of protein localization	33/300	979/17913	0.0001	0.0016	33
GO:0010563	negative regulation of phosphorus metabolic process	23/300	574/17913	0.0001	0.0016	23
GO:0071241	cellular response to inorganic substance	12/300	194/17913	0.0001	0.0016	12
GO:2000377	regulation of reactive oxygen species metabolic process	12/300	194/17913	0.0001	0.0016	12
GO:0044843	cell cycle G1/S phase transition	15/300	288/17913	0.0001	0.0016	15
GO:0031329	regulation of cellular catabolic process	29/300	814/17913	0.0001	0.0016	29
GO:0016241	regulation of macroautophagy	11/300	166/17913	0.0001	0.0017	11
GO:0097067	cellular response to thyroid hormone stimulus	4/300	16/17913	0.0001	0.0017	4
GO:2000147	positive regulation of cell motility	22/300	540/17913	0.0001	0.0017	22
GO:0071248	cellular response to metal ion	11/300	167/17913	0.0001	0.0017	11
GO:0030098	lymphocyte differentiation	16/300	325/17913	0.0001	0.0018	16
GO:0002200	somatic diversification of immune receptors	7/300	67/17913	0.0001	0.0018	7
GO:0010743	regulation of macrophage derived foam cell differentiation	5/300	30/17913	0.0001	0.0018	5
GO:0061082	myeloid leukocyte cytokine production	5/300	30/17913	0.0001	0.0018	5
GO:1901699	cellular response to nitrogen compound	24/300	620/17913	0.0001	0.0018	24
GO:0045639	positive regulation of myeloid cell differentiation	8/300	90/17913	0.0001	0.0019	8
GO:0001934	positive regulation of protein phosphorylation	31/300	907/17913	0.0001	0.0019	31
GO:0050670	regulation of lymphocyte proliferation	12/300	199/17913	0.0001	0.0019	12
GO:0000041	transition metal ion transport	8/300	91/17913	0.0001	0.0020	8
GO:0060333	interferon-gamma-mediated signaling pathway	8/300	91/17913	0.0001	0.0020	8
GO:0042327	positive regulation of phosphorylation	32/300	955/17913	0.0002	0.0021	32
GO:0010744	positive regulation of macrophage derived foam cell differentiation	4/300	17/17913	0.0002	0.0021	4
GO:0007596	blood coagulation	16/300	331/17913	0.0002	0.0021	16
GO:0042060	wound healing	22/300	550/17913	0.0002	0.0021	22
GO:0019216	regulation of lipid metabolic process	18/300	402/17913	0.0002	0.0022	18
GO:1902749	regulation of cell cycle G2/M phase transition	12/300	202/17913	0.0002	0.0022	12
GO:0006935	chemotaxis	22/300	551/17913	0.0002	0.0022	22
GO:0016447	somatic recombination of immunoglobulin gene segments	6/300	49/17913	0.0002	0.0022	6
GO:0034341	response to interferon-gamma	11/300	173/17913	0.0002	0.0022	11
GO:0051897	positive regulation of protein kinase B signaling	11/300	173/17913	0.0002	0.0022	11
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	9/300	118/17913	0.0002	0.0022	9
GO:0042330	taxis	22/300	553/17913	0.0002	0.0023	22
GO:0045597	positive regulation of cell differentiation	32/300	962/17913	0.0002	0.0023	32
GO:0033028	myeloid cell apoptotic process	5/300	32/17913	0.0002	0.0024	5
GO:0006259	DNA metabolic process	32/300	964/17913	0.0002	0.0024	32
GO:0045851	pH reduction	6/300	50/17913	0.0002	0.0024	6
GO:0099024	plasma membrane invagination	6/300	50/17913	0.0002	0.0024	6
GO:1905517	macrophage migration	6/300	50/17913	0.0002	0.0024	6
GO:0007229	integrin-mediated signaling pathway	8/300	94/17913	0.0002	0.0024	8
GO:0060627	regulation of vesicle-mediated transport	20/300	480/17913	0.0002	0.0024	20
GO:0000082	G1/S transition of mitotic cell cycle	14/300	269/17913	0.0002	0.0024	14
GO:0002224	toll-like receptor signaling pathway	10/300	147/17913	0.0002	0.0025	10
GO:0050817	coagulation	16/300	337/17913	0.0002	0.0025	16
GO:0033273	response to vitamin	8/300	95/17913	0.0002	0.0025	8
GO:0009410	response to xenobiotic stimulus	14/300	270/17913	0.0002	0.0025	14
GO:0006882	cellular zinc ion homeostasis	4/300	18/17913	0.0002	0.0025	4
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	4/300	18/17913	0.0002	0.0025	4
GO:0051047	positive regulation of secretion	18/300	409/17913	0.0002	0.0025	18
GO:0002712	regulation of B cell mediated immunity	6/300	51/17913	0.0002	0.0026	6
GO:0002889	regulation of immunoglobulin mediated immune response	6/300	51/17913	0.0002	0.0026	6
GO:0002687	positive regulation of leukocyte migration	9/300	121/17913	0.0002	0.0026	9
GO:0016242	negative regulation of macroautophagy	5/300	33/17913	0.0002	0.0026	5
GO:0042554	superoxide anion generation	5/300	33/17913	0.0002	0.0026	5
GO:0045191	regulation of isotype switching	5/300	33/17913	0.0002	0.0026	5
GO:0097242	amyloid-beta clearance	5/300	33/17913	0.0002	0.0026	5
GO:0051169	nuclear transport	15/300	305/17913	0.0002	0.0026	15
GO:0048545	response to steroid hormone	17/300	375/17913	0.0002	0.0026	17
GO:0016236	macroautophagy	14/300	272/17913	0.0002	0.0026	14
GO:0040013	negative regulation of locomotion	17/300	377/17913	0.0002	0.0028	17
GO:0001909	leukocyte mediated cytotoxicity	8/300	97/17913	0.0002	0.0028	8
GO:0006909	phagocytosis	15/300	308/17913	0.0002	0.0028	15
GO:0045930	negative regulation of mitotic cell cycle	15/300	308/17913	0.0002	0.0028	15
GO:0043542	endothelial cell migration	14/300	275/17913	0.0002	0.0029	14
GO:0055072	iron ion homeostasis	7/300	74/17913	0.0002	0.0029	7
GO:0006163	purine nucleotide metabolic process	21/300	528/17913	0.0002	0.0029	21
GO:0051099	positive regulation of binding	11/300	181/17913	0.0002	0.0030	11
GO:0070838	divalent metal ion transport	19/300	454/17913	0.0002	0.0030	19
GO:0005996	monosaccharide metabolic process	14/300	277/17913	0.0003	0.0031	14
GO:0042326	negative regulation of phosphorylation	19/300	455/17913	0.0003	0.0031	19
GO:0002763	positive regulation of myeloid leukocyte differentiation	6/300	54/17913	0.0003	0.0033	6
GO:1903078	positive regulation of protein localization to plasma membrane	6/300	54/17913	0.0003	0.0033	6
GO:0046822	regulation of nucleocytoplasmic transport	8/300	100/17913	0.0003	0.0033	8
GO:0072511	divalent inorganic cation transport	19/300	458/17913	0.0003	0.0033	19
GO:0006164	purine nucleotide biosynthetic process	14/300	280/17913	0.0003	0.0034	14
GO:1903555	regulation of tumor necrosis factor superfamily cytokine production	10/300	155/17913	0.0003	0.0034	10
GO:0002367	cytokine production involved in immune response	8/300	101/17913	0.0003	0.0035	8
GO:0033194	response to hydroperoxide	4/300	20/17913	0.0003	0.0035	4
GO:0055069	zinc ion homeostasis	4/300	20/17913	0.0003	0.0035	4
GO:0071636	positive regulation of transforming growth factor beta production	4/300	20/17913	0.0003	0.0035	4
GO:0009636	response to toxic substance	20/300	499/17913	0.0003	0.0035	20
GO:0034109	homotypic cell-cell adhesion	7/300	77/17913	0.0003	0.0035	7
GO:0016445	somatic diversification of immunoglobulins	6/300	55/17913	0.0003	0.0035	6
GO:0031663	lipopolysaccharide-mediated signaling pathway	6/300	55/17913	0.0003	0.0035	6
GO:0042306	regulation of protein import into nucleus	6/300	55/17913	0.0003	0.0035	6
GO:0008286	insulin receptor signaling pathway	9/300	128/17913	0.0003	0.0036	9
GO:0032355	response to estradiol	9/300	128/17913	0.0003	0.0036	9
GO:1905521	regulation of macrophage migration	5/300	36/17913	0.0003	0.0036	5
GO:1903829	positive regulation of cellular protein localization	15/300	318/17913	0.0003	0.0037	15
GO:0017157	regulation of exocytosis	11/300	187/17913	0.0003	0.0037	11
GO:0010595	positive regulation of endothelial cell migration	9/300	129/17913	0.0003	0.0037	9
GO:0022617	extracellular matrix disassembly	7/300	78/17913	0.0003	0.0038	7
GO:0001666	response to hypoxia	16/300	354/17913	0.0003	0.0038	16
GO:0010631	epithelial cell migration	16/300	354/17913	0.0003	0.0038	16
GO:1903202	negative regulation of oxidative stress-induced cell death	6/300	56/17913	0.0003	0.0038	6
GO:0043535	regulation of blood vessel endothelial cell migration	10/300	158/17913	0.0003	0.0038	10
GO:0048524	positive regulation of viral process	8/300	103/17913	0.0003	0.0038	8
GO:0032868	response to insulin	13/300	252/17913	0.0003	0.0039	13
GO:0030212	hyaluronan metabolic process	5/300	37/17913	0.0004	0.0040	5
GO:0032101	regulation of response to external stimulus	29/300	873/17913	0.0004	0.0040	29
GO:0090132	epithelium migration	16/300	357/17913	0.0004	0.0040	16
GO:0090087	regulation of peptide transport	25/300	706/17913	0.0004	0.0041	25
GO:0006925	inflammatory cell apoptotic process	4/300	21/17913	0.0004	0.0041	4
GO:0046686	response to cadmium ion	6/300	57/17913	0.0004	0.0041	6
GO:1900408	negative regulation of cellular response to oxidative stress	6/300	57/17913	0.0004	0.0041	6
GO:1902041	regulation of extrinsic apoptotic signaling pathway via death domain receptors	6/300	57/17913	0.0004	0.0041	6
GO:0006886	intracellular protein transport	28/300	833/17913	0.0004	0.0041	28
GO:0017144	drug metabolic process	27/300	792/17913	0.0004	0.0042	27
GO:0071706	tumor necrosis factor superfamily cytokine production	10/300	161/17913	0.0004	0.0043	10
GO:0001558	regulation of cell growth	17/300	396/17913	0.0004	0.0043	17
GO:0009165	nucleotide biosynthetic process	16/300	360/17913	0.0004	0.0043	16
GO:0010324	membrane invagination	6/300	58/17913	0.0004	0.0044	6
GO:1904589	regulation of protein import	6/300	58/17913	0.0004	0.0044	6
GO:0050851	antigen receptor-mediated signaling pathway	12/300	224/17913	0.0004	0.0045	12
GO:0072522	purine-containing compound biosynthetic process	14/300	291/17913	0.0004	0.0045	14
GO:0035690	cellular response to drug	16/300	362/17913	0.0004	0.0045	16
GO:0090130	tissue migration	16/300	363/17913	0.0004	0.0047	16
GO:1990748	cellular detoxification	8/300	107/17913	0.0004	0.0047	8
GO:0016051	carbohydrate biosynthetic process	11/300	194/17913	0.0004	0.0047	11
GO:0000715	nucleotide-excision repair, DNA damage recognition	4/300	22/17913	0.0004	0.0047	4
GO:1902883	negative regulation of response to oxidative stress	6/300	59/17913	0.0004	0.0048	6
GO:2001056	positive regulation of cysteine-type endopeptidase activity	9/300	135/17913	0.0005	0.0048	9
GO:1901293	nucleoside phosphate biosynthetic process	16/300	365/17913	0.0005	0.0049	16
GO:0051223	regulation of protein transport	24/300	677/17913	0.0005	0.0050	24
GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	14/300	295/17913	0.0005	0.0050	14
GO:0002706	regulation of lymphocyte mediated immunity	9/300	136/17913	0.0005	0.0050	9
GO:1903305	regulation of regulated secretory pathway	9/300	136/17913	0.0005	0.0050	9
GO:0045582	positive regulation of T cell differentiation	7/300	83/17913	0.0005	0.0050	7
GO:0050727	regulation of inflammatory response	19/300	479/17913	0.0005	0.0051	19
GO:0032869	cellular response to insulin stimulus	11/300	197/17913	0.0005	0.0052	11
GO:0007417	central nervous system development	30/300	935/17913	0.0005	0.0052	30
GO:0071417	cellular response to organonitrogen compound	21/300	559/17913	0.0005	0.0052	21
GO:0070201	regulation of establishment of protein localization	25/300	723/17913	0.0005	0.0053	25
GO:0072521	purine-containing compound metabolic process	21/300	560/17913	0.0005	0.0053	21
GO:0071621	granulocyte chemotaxis	7/300	84/17913	0.0005	0.0053	7
GO:0071677	positive regulation of mononuclear cell migration	4/300	23/17913	0.0005	0.0055	4
GO:1904377	positive regulation of protein localization to cell periphery	6/300	61/17913	0.0005	0.0055	6
GO:0030278	regulation of ossification	11/300	199/17913	0.0005	0.0056	11
GO:0006898	receptor-mediated endocytosis	14/300	301/17913	0.0006	0.0059	14
GO:0002639	positive regulation of immunoglobulin production	5/300	41/17913	0.0006	0.0059	5
GO:0032623	interleukin-2 production	6/300	62/17913	0.0006	0.0060	6
GO:0017038	protein import	9/300	140/17913	0.0006	0.0060	9
GO:0061024	membrane organization	25/300	730/17913	0.0006	0.0060	25
GO:0098655	cation transmembrane transport	25/300	730/17913	0.0006	0.0060	25
GO:0001959	regulation of cytokine-mediated signaling pathway	10/300	170/17913	0.0006	0.0060	10
GO:0097529	myeloid leukocyte migration	10/300	170/17913	0.0006	0.0060	10
GO:0006913	nucleocytoplasmic transport	14/300	302/17913	0.0006	0.0060	14
GO:0072507	divalent inorganic cation homeostasis	17/300	412/17913	0.0006	0.0061	17
GO:0043491	protein kinase B signaling	13/300	268/17913	0.0006	0.0061	13
GO:0000188	inactivation of MAPK activity	4/300	24/17913	0.0006	0.0062	4
GO:0043433	negative regulation of DNA-binding transcription factor activity	10/300	171/17913	0.0006	0.0062	10
GO:0051347	positive regulation of transferase activity	22/300	609/17913	0.0006	0.0062	22
GO:0030183	B cell differentiation	8/300	113/17913	0.0006	0.0062	8
GO:0098754	detoxification	8/300	113/17913	0.0006	0.0062	8
GO:0046637	regulation of alpha-beta T cell differentiation	6/300	63/17913	0.0006	0.0063	6
GO:0071277	cellular response to calcium ion	6/300	63/17913	0.0006	0.0063	6
GO:2000117	negative regulation of cysteine-type endopeptidase activity	7/300	87/17913	0.0006	0.0063	7
GO:0006816	calcium ion transport	17/300	415/17913	0.0007	0.0065	17
GO:0050792	regulation of viral process	11/300	204/17913	0.0007	0.0066	11
GO:0001933	negative regulation of protein phosphorylation	17/300	416/17913	0.0007	0.0067	17
GO:0002286	T cell activation involved in immune response	7/300	88/17913	0.0007	0.0067	7
GO:0010634	positive regulation of epithelial cell migration	10/300	173/17913	0.0007	0.0067	10
GO:0002323	natural killer cell activation involved in immune response	3/300	11/17913	0.0007	0.0067	3
GO:0019321	pentose metabolic process	3/300	11/17913	0.0007	0.0067	3
GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	3/300	11/17913	0.0007	0.0067	3
GO:0045670	regulation of osteoclast differentiation	6/300	64/17913	0.0007	0.0067	6
GO:0000086	G2/M transition of mitotic cell cycle	12/300	238/17913	0.0007	0.0068	12
GO:2001239	regulation of extrinsic apoptotic signaling pathway in absence of ligand	5/300	43/17913	0.0007	0.0070	5
GO:1903532	positive regulation of secretion by cell	16/300	381/17913	0.0007	0.0070	16
GO:0002824	positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	7/300	89/17913	0.0007	0.0070	7
GO:0045672	positive regulation of osteoclast differentiation	4/300	25/17913	0.0007	0.0070	4
GO:0097066	response to thyroid hormone	4/300	25/17913	0.0007	0.0070	4
GO:0006801	superoxide metabolic process	6/300	65/17913	0.0008	0.0072	6
GO:0051346	negative regulation of hydrolase activity	17/300	420/17913	0.0008	0.0072	17
GO:0006790	sulfur compound metabolic process	15/300	346/17913	0.0008	0.0073	15
GO:0051896	regulation of protein kinase B signaling	12/300	241/17913	0.0008	0.0074	12
GO:0097237	cellular response to toxic substance	12/300	241/17913	0.0008	0.0074	12
GO:1900180	regulation of protein localization to nucleus	8/300	117/17913	0.0008	0.0074	8
GO:0043524	negative regulation of neuron apoptotic process	9/300	146/17913	0.0008	0.0075	9
GO:0002708	positive regulation of lymphocyte mediated immunity	7/300	91/17913	0.0008	0.0078	7
GO:0007051	spindle organization	9/300	147/17913	0.0008	0.0078	9
GO:0010951	negative regulation of endopeptidase activity	11/300	210/17913	0.0009	0.0080	11
GO:2000679	positive regulation of transcription regulatory region DNA binding	4/300	26/17913	0.0009	0.0080	4
GO:0048589	developmental growth	22/300	624/17913	0.0009	0.0080	22
GO:1902600	proton transmembrane transport	9/300	148/17913	0.0009	0.0082	9
GO:0051928	positive regulation of calcium ion transport	8/300	119/17913	0.0009	0.0082	8
GO:0070227	lymphocyte apoptotic process	6/300	67/17913	0.0009	0.0082	6
GO:0001503	ossification	16/300	388/17913	0.0009	0.0082	16
GO:0051701	interaction with host	11/300	211/17913	0.0009	0.0082	11
GO:0043409	negative regulation of MAPK cascade	10/300	179/17913	0.0009	0.0082	10
GO:0032103	positive regulation of response to external stimulus	14/300	315/17913	0.0009	0.0083	14
GO:0072657	protein localization to membrane	20/300	545/17913	0.0009	0.0083	20
GO:0042308	negative regulation of protein import into nucleus	3/300	12/17913	0.0009	0.0083	3
GO:0051238	sequestering of metal ion	3/300	12/17913	0.0009	0.0083	3
GO:1904590	negative regulation of protein import	3/300	12/17913	0.0009	0.0083	3
GO:0045621	positive regulation of lymphocyte differentiation	7/300	93/17913	0.0010	0.0086	7
GO:0046364	monosaccharide biosynthetic process	7/300	93/17913	0.0010	0.0086	7
GO:1903076	regulation of protein localization to plasma membrane	7/300	93/17913	0.0010	0.0086	7
GO:0071674	mononuclear cell migration	6/300	68/17913	0.0010	0.0086	6
GO:0072503	cellular divalent inorganic cation homeostasis	16/300	392/17913	0.0010	0.0089	16
GO:0007160	cell-matrix adhesion	11/300	214/17913	0.0010	0.0089	11
GO:0032673	regulation of interleukin-4 production	4/300	27/17913	0.0010	0.0089	4
GO:0090068	positive regulation of cell cycle process	13/300	283/17913	0.0010	0.0090	13
GO:0002821	positive regulation of adaptive immune response	7/300	94/17913	0.0010	0.0090	7
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	7/300	94/17913	0.0010	0.0090	7
GO:0032680	regulation of tumor necrosis factor production	9/300	151/17913	0.0010	0.0090	9
GO:0042552	myelination	8/300	122/17913	0.0010	0.0092	8
GO:0046390	ribose phosphate biosynthetic process	13/300	284/17913	0.0010	0.0093	13
GO:0030168	platelet activation	9/300	152/17913	0.0011	0.0094	9
GO:0002768	immune response-regulating cell surface receptor signaling pathway	17/300	434/17913	0.0011	0.0095	17
GO:0030162	regulation of proteolysis	25/300	762/17913	0.0011	0.0095	25
GO:0002204	somatic recombination of immunoglobulin genes involved in immune response	5/300	47/17913	0.0011	0.0095	5
GO:0002208	somatic diversification of immunoglobulins involved in immune response	5/300	47/17913	0.0011	0.0095	5
GO:0043370	regulation of CD4-positive, alpha-beta T cell differentiation	5/300	47/17913	0.0011	0.0095	5
GO:0045190	isotype switching	5/300	47/17913	0.0011	0.0095	5
GO:0045815	positive regulation of gene expression, epigenetic	5/300	47/17913	0.0011	0.0095	5
GO:0046638	positive regulation of alpha-beta T cell differentiation	5/300	47/17913	0.0011	0.0095	5
GO:0043393	regulation of protein binding	11/300	217/17913	0.0011	0.0097	11
GO:0050871	positive regulation of B cell activation	6/300	70/17913	0.0011	0.0097	6
GO:0042692	muscle cell differentiation	15/300	359/17913	0.0011	0.0097	15
GO:0036296	response to increased oxygen levels	4/300	28/17913	0.0011	0.0099	4
GO:0090383	phagosome acidification	4/300	28/17913	0.0011	0.0099	4
GO:0042177	negative regulation of protein catabolic process	8/300	124/17913	0.0012	0.0099	8